Mid-trimester maternal serum markers in predicting adverse pregnancy outcome
| Main Authors: | Androutsopoulos Georgios, Gkogkos Panagiotis, Papadopoulos Vassilios, Adonakis Georgios, Tsapanos Vassilios, Vassilakos Pavlos, Panayiotakis Georgios, Decavalas Georgios |
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| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2009
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/6033768 |
Daftar Isi:
- Objective: In our prospective study, we investigated the association between mid-trimester maternal serum AFP (ms-AFP), maternal serum hCG (ms-hCG) levels and adverse pregnancy outcome, in the South-Western Greek population. Materials and Methods: 126 healthy Greek women with spontaneous pregnancies, investigated for ms-AFP and ms-hCG levels between 13th-24th weeks of gestation and followed for adverse pregnancy outcome. As abnormal were considered ms-AFP levels or ms-hCG levels > 2.0 multiples of the median value for gestation (MoM). Statistical analysis was performed by Pearson’s chi-square test. Results: Elevated ms-AFP levels were detected in a total of 25 from the 126 women studied (19.84%). Elevated ms-hCG levels were detected in a total of 10 from the 126 women studied (7.93%). Elevated ms-AFP and ms-hCG levels were detected in a total of 4 from the 126 women studied (3.17%). Conclusion: Multiparameter testing of placental function in the mid-trimester (uterine artery Doppler, placental morphology, ms-AFP and ms-hCG screening) may allow us to identify women with increased risk to develop severe placental insufficiency and pregnancy complications.