endometrial cancer Uterine myomas cervical cancer colposcopy cytology molecular biology ovarian cancer synchronous primary cancers AFP levels EGF system ErbB receptors HPV HPV vaccination adverse pregnancy outcome biomarkers cerbB receptors cervical glandular lesions cervical screening clinical significance diagnostic investigations endocytosis epidermal growth factor system expression hCG levels immunotherapy infection intracellular trafficking maternal serum markers nuclear entry pregnancy prognosis radiotherapy receptors scleroderma sentinel lymph node dissection surgery systematic lymphadenectomy systematic surgical staging treatment options vaginal melanoma