endometrial cancer treatment adverse pregnancy outcome cervical cancer surgery synchronous primary cancers LEEP electrosurgery maternal serum markers ovarian cancer prognosis vaginal primary malignant melanoma AFP Uterine myomas VAIN chemotherapy clinical characteristics colposcopy cytology hCG molecular biology radiotherapy vaginal intraepithelial neoplasia AFP levels EGF system ErbB receptors Factor II G20210A Factor V Leiden HPV HPV vaccination MTHFR C677T VIN biomarkers breast carcinoma cerbB receptors cervical glandular lesions cervical screening clinical significance combined inherited thrombophilia diagnosis diagnostic investigations endocytosis epidemiology epidermal growth factor system expression hCG levels immunotherapy infection intracellular trafficking mammographic appearance