endometrial cancer treatment cervical cancer clinical characteristics colposcopy cytology molecular biology surgery vaginal primary malignant melanoma ErbB receptors HPV HPV vaccination biomarkers breast carcinoma cervical glandular lesions cervical screening clinical significance diagnostic investigations endocytosis epidermal growth factor system expression infection intracellular trafficking mammographic appearance molecular prognostic factors nuclear entry pregnancy receptors sentinel lymph node dissection synchronous primary cancers systematic lymphadenectomy systematic surgical staging treatment options