Expression of the epidermal growth factor system in endometrial cancer
| Main Authors: | Adonakis Georgios, Androutsopoulos Georgios, Koumoundourou Dimitra, Liava Anna, Ravazoula Panagiota, Kourounis Georgios |
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| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2008
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/6027378 |
Daftar Isi:
- Objective. The aim of our study was to describe the expression of cerbB-1, cerbB-2, cerbB-3 and cerbB-4 in endometrial cancer tissue and its correlation with clinicopathologic features and prognosis of the patients. Study Design. 106 cases of endometrial cancer were identified from the archives of the Department of Obstetrics and Gynecology of the University of Patras. Tissue specimens from endometrial lesions were immunostained for cerbB-1, cerbB-2, cerbB-3 and cerbB-4. Statistical analyses were performed using chi square test, Kaplan-Meier method and Cox analysis. Results. We found a significant association between cerbB-1 expression and patients’ survival. A reverse correlation was found between tumor grade and cerbB-1 expression. The tumor grade was not significantly correlated with the expression of the rest three receptors. The stage of the tumor showed no relationship with the expression of these receptors. Conclusion. The ability to predict increased risks of advanced disease, recurrence, and death from abnormal molecular markers detected in curettage or endometrial biopsy specimens will facilitate pretreatment referral of these patients to gynecologic oncologists for definitive surgical treatment.