Optimasi Formula Gel Antibakteri Ekstrak Kulit Buah Manggis(Garcinia mangostana Linn.) Menggunakan HPMC Sebagai Gelling Agent dan Propilen Glikol Sebagai Humektan Dengan Metode Desain Faktorial
| Main Author: | Arumsasi, Anggita Sekar |
|---|---|
| Format: | Karya Ilmiah NonPeerReviewed application/pdf |
| Bahasa: | eng |
| Terbitan: |
, 2015
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| Subjects: | |
| Online Access: |
http://eprints.ums.ac.id/33671/1/NASKAH%20PUBLIKASI.pdf http://eprints.ums.ac.id/33671/2/HALAMAN%20DEPAN.pdf http://eprints.ums.ac.id/33671/3/BAB%20I.pdf http://eprints.ums.ac.id/33671/5/BAB%20II.pdf http://eprints.ums.ac.id/33671/6/BAB%20III.pdf http://eprints.ums.ac.id/33671/8/BAB%20IV.pdf http://eprints.ums.ac.id/33671/9/DAFTAR%20PUSTAKA.pdf http://eprints.ums.ac.id/33671/10/LAMPIRAN.pdf http://eprints.ums.ac.id/33671/11/SURAT%20PERNYATAAN%20PUBLIKASI%20ILMIAH.pdf http://eprints.ums.ac.id/33671/ |
Daftar Isi:
- Mangosteen peel contains xanton derivatives (α-mangostin) which has antibacterial activity against Staphylococcus aureus. In order to facilitate its use then made into a gel formulation. The purpose of this study was to determine the gel formula extract mangosteen peel optimum use of HPMC (Hydroxy Propyl Methyl Cellulose) as a gelling agent and propylene glycol as a humectant by factorial design method. Gel evaluation was conducted on the organoleptic, homogeneity, viscosity, pH, adhesion test, spread test, and physical stability for 1 month and test of antibacterial activity against Staphylococcus aureus with well diffusion method. Formula evaluation results were then analyzed using a factorial design method and one sample t-test to compare the predicted results with the optimum formula experimental verification. Optimum gel stability test results were analyzed with independent samples T Test. The results showed that the optimum gel formula mangosteen peel extract is HPMC 14% and 20% propylene glycol. HPMC combination of 14% and 20% propylene glycol can increase the viscosity, pH, adhesion and antibacterial activity and can decrease the spread gel. Optimum gel mangosteen peel extract stored for 1 month had a pH, adhesion, dispersive power, and the antibacterial activity is quite stable, while the viscosity of the gel is less stable.