Can a Multi-Epitope Vaccine be a solution for COVID-19 pandemic?
| Main Author: | Domina Petric |
|---|---|
| Format: | info publication-preprint Journal |
| Terbitan: |
, 2021
|
| Online Access: |
https://zenodo.org/record/5233404 |
Daftar Isi:
- Problems associated with Wuhan spike protein-based vaccines are the emergence of new SARS-CoV-2 strains that are more or less resistant to Wuhan spike protein-based vaccine-induced immunity, and toxicity of the spike protein (S protein alone can damage vascular endothelial cells). Multi-epitope vaccine against SARS-CoV-2, excluding the spike protein, could potentially be less toxic than Wuhan spike protein-based vaccines with less serious side effects, but still enough immunogenic to elicit protective immune response. Another potential benefit of a multi-epitope COVID-19 vaccine is that, taking into account the fact that most of the new SARS-CoV-2 strains carry significant new mutations in the spike protein and less significant mutations in other structural proteins of the virus, it could provide more potent immune response against new SARS-CoV-2 variants.