Can a Multi-Epitope Vaccine be a solution for COVID-19 pandemic?
| Main Author: | Domina Petric |
|---|---|
| Format: | info publication-preprint Journal |
| Terbitan: |
, 2021
|
| Online Access: |
https://zenodo.org/record/5233404 |
| ctrlnum |
5233404 |
|---|---|
| fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><creator>Domina Petric</creator><date>2021-08-22</date><description>Problems associated with Wuhan spike protein-based vaccines are the emergence of new SARS-CoV-2 strains that are more or less resistant to Wuhan spike protein-based vaccine-induced immunity, and toxicity of the spike protein (S protein alone can damage vascular endothelial cells).
Multi-epitope vaccine against SARS-CoV-2, excluding the spike protein, could potentially be less toxic than Wuhan spike protein-based vaccines with less serious side effects, but still enough immunogenic to elicit protective immune response. Another potential benefit of a multi-epitope COVID-19 vaccine is that, taking into account the fact that most of the new SARS-CoV-2 strains carry significant new mutations in the spike protein and less significant mutations in other structural proteins of the virus, it could provide more potent immune response against new SARS-CoV-2 variants.</description><identifier>https://zenodo.org/record/5233404</identifier><identifier>10.5281/zenodo.5233404</identifier><identifier>oai:zenodo.org:5233404</identifier><relation>doi:10.5281/zenodo.5233403</relation><relation>url:https://zenodo.org/communities/covid-19</relation><rights>info:eu-repo/semantics/openAccess</rights><rights>https://creativecommons.org/licenses/by/4.0/legalcode</rights><title>Can a Multi-Epitope Vaccine be a solution for COVID-19 pandemic?</title><type>Other:info:eu-repo/semantics/preprint</type><type>Other:publication-preprint</type><recordID>5233404</recordID></dc>
|
| format |
Other:info:eu-repo/semantics/preprint Other Other:publication-preprint Journal:Journal Journal |
| author |
Domina Petric |
| title |
Can a Multi-Epitope Vaccine be a solution for COVID-19 pandemic? |
| publishDate |
2021 |
| url |
https://zenodo.org/record/5233404 |
| contents |
Problems associated with Wuhan spike protein-based vaccines are the emergence of new SARS-CoV-2 strains that are more or less resistant to Wuhan spike protein-based vaccine-induced immunity, and toxicity of the spike protein (S protein alone can damage vascular endothelial cells).
Multi-epitope vaccine against SARS-CoV-2, excluding the spike protein, could potentially be less toxic than Wuhan spike protein-based vaccines with less serious side effects, but still enough immunogenic to elicit protective immune response. Another potential benefit of a multi-epitope COVID-19 vaccine is that, taking into account the fact that most of the new SARS-CoV-2 strains carry significant new mutations in the spike protein and less significant mutations in other structural proteins of the virus, it could provide more potent immune response against new SARS-CoV-2 variants. |
| id |
IOS16997.5233404 |
| institution |
ZAIN Publications |
| institution_id |
7213 |
| institution_type |
library:special library |
| library |
Cognizance Journal of Multidisciplinary Studies |
| library_id |
5267 |
| collection |
Cognizance Journal of Multidisciplinary Studies |
| repository_id |
16997 |
| subject_area |
Multidisciplinary |
| city |
Stockholm |
| province |
INTERNASIONAL |
| shared_to_ipusnas_str |
1 |
| repoId |
IOS16997 |
| first_indexed |
2022-06-06T06:54:40Z |
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2022-06-06T06:54:40Z |
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dc |
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1734910591992070144 |
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17.538404 |