Design, Formulation Development and Evaluation of Matrix Tablet Containing Labetalol HCL
| Main Authors: | Dileep Kumar Awasthi, Sangamesh B. Puranik, Rohit Saraswat, Mahesh Kumar Jhajharia, Prashant Sharma |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2020
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4090901 |
Daftar Isi:
- Abstract— The objective of present work was to design and develop sustained release matrix tablets of anti-hypertensive drug Labetalol hydrochloride. Hydroxypropyl methyl cellulose K15, Sodium CMC, Xanthan gum and Tamarind seed polysaccharide used as a rate retarding polymer. Whereas Polyvinyl Pyrrolidone and Microcrystalline cellulose are used as granulating agent and diluent. The influence of variable concentration of polymers on the release rate of drug was investigated. The results of the present work point out that the rate of Labetalol hydrochloride release from polymers like Hydroxypropyl methyl cellulose K15, Sodium CMC, Xanthan gum and Tamarind seed polysaccharide are mainly controlled by the drug–polymer ratio. The prepared sustained release matrix tablets were evaluated for various parameters like hardness, friability, uniformity of weight, uniformity of drug content and in vitro drug release studies.