Piper cubeba 1-b][1 2 3 4-Diaminoquinazoline Dioxygenase 4] Acyclovir Anti-Inflammatory Agents Anti-fungal Anti-tubercular Antibacterial Agents Antioxidant activity Bacteriocin Compound Sturcture DPPH DoE Drug delivery Escherichia coli Hydroxypropyl methyl cellulose K15 Imidazo[2 Labetalol hydrochloride Formulation Microsponge One-pot synthesis Phytochemical Piper nigrum QbD Quinazolinone derivatives Sodium CMC Sustained-release Tuberculosis Mycobacterium tuberculosis Antibacterial activity Vilsmeier reaction Xanthan gum and Tamarind seed polysaccharide labetalol hydrochloride penetration enhancer plant extract skin permeation thiadiazole-5-carbaldehyde transdermal