Pengaruh Ekstrak Daun Singawalang Terhadap Kadar LDL Tikus Putih Jantan Hiperkolesterolemia
| Main Authors: | Claudi Artha; Fakultas Kedokteran Universitas Airlangga, Arifa Mustika; Departemen Farmakologi Fakultas Kedokteran Universitas Airlangga, Sri Wijayanti Sulistyawati; Departemen Parasitologi Fakultas Kedokteran Universitas Airlangga |
|---|---|
| Format: | Article application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Faculty of Medicine Universitas Indonesia
, 2017
|
| Subjects: | |
| Online Access: |
http://journal.ui.ac.id/index.php/eJKI/article/view/7151 http://journal.ui.ac.id/index.php/eJKI/article/download/7151/13454 http://journal.ui.ac.id/index.php/eJKI/article/download/7151/13455 |
Daftar Isi:
- Hypercholesterolemia is a condition of high cholesterol in the blood that is characterized by elevated levels of LDL without elevated triglyceride levels. Thus, currently the use of herbal medicines by utilizing plant biotic compounds being developed. Petiveria Alliaceae or known as singawalang can decrease levels of LDL cholesterol in the blood because of the content of compounds such as flavonoids, alkaloids, and tannins. This study is a laboratory experimental research with pre and posttest control group design. Sample using rats (Rattus norvegicus) males, aged 2-3 months with body weight ± 150 grams. The average LDL cholesterol level of negative control group (KN) is 3.40 ± 2.07, which means there is no significant increase. In the simvastatin group (S), the treatment group 1 (K1), group 2 (K2), and treatment group 3 (K3) the average of LDL cholesterol results showed a decrease with the result S = -71.10 ± 31.35, K1 = -53.60 ± 26.80, K2 = -67.05 ± 23.98, and K3 = -51.06 ± 20.27. By using One Way Anova obtained significance value of p <0.05, which showed significant differences between group KN with group S, K1, K2, K3.