The Effectiveness of Clomiphene Citrate and Letrozole for Ovulation Induction Related to Endometrial Thickness and Number of Dominant Follicle
| Main Authors: | Budi Wiweko; Department of Obstetric and Gynecologic FM Universitas Indonesia- Dr. Cipto Mangunkusumo National Hospital, Endy M. Moegni; Department of Obstetric and Gynecologic FM Universitas Indonesia- Dr. Cipto Mangunkusumo National Hospital, Veinardi Madjid; Department of Obstetric and Gynecologic FM Universitas Indonesia- Dr. Cipto Mangunkusumo National Hospital, Mushlihani Mushlihani; Department of Obstetric and Gynecologic FM Universitas Indonesia- Dr. Cipto Mangunkusumo National Hospital |
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| Format: | Article application/x-download eJournal |
| Bahasa: | eng |
| Terbitan: |
Fakultas Kedokteran Universitas Indonesia
, 2016
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| Online Access: |
http://journal.ui.ac.id/index.php/eJKI/article/view/6285 |
Daftar Isi:
- The aim of the study is to know the effectiveness of clomiphene citrate and letrozole for ovulationrelated to endometrial thickness and number of dominant follicle. Study design was cross sectional basedon medical records of women who underwent ovulation induction from January 2011-May 2015. A numberof 143 anovulation women were divided into clomiphene citrate 50mg, clomiphene citrate 100 mg, letrozole2.5mg and letrozole 5mg. Each group received the agent daily on 3rd-7th day of menstrual cycle. On 12thday of menstrual cycle, the transvaginal ultrasound was performed to measure endometrial thickness anddominant follicle number. From all subjects, 45 subjects (31.5%) were in 50mg clomiphene citrate groups, 29subjects (20.3%) in 100mg clomiphene citrate group, 23 subjects (16.1%) in 2,5mg letrozole group, and 46subjects (32.2%) in 5mg letrozole group. Subjects who received letrozole had thicker endometrium comparedto clomiphene citrate (p<0.05). Different doses were not associated with endometrial thickness betweensubjects who received either letrozole or clomiphene citrate. In addition, subjects receiving letrozole hadhigher proportion of having trilaminar endometrium morphology. We did not observe the difference in totalnumber of dominant follicle between groups. It is concluded that letrozole is more effective than clomiphenecitrate in terms of endometrial thickness but not for number of dominant follicles. Keywords: clomiphene citrate, letrozole, ovulation induction, endometrial thickness, dominant follicle Efektivitas Induksi Ovulasi Klomifen Sitrat dan Letrozol dalam Hal KetebalanEndometrium dan Jumlah Folikel Dominan Abstrak Studi ini bertujuan untuk menilai efektivitas induksi ovulasi klomifen sitrat dan letrozol dalam halketebalan endometrium dan jumlah folikel dominan pada perempuan yang tidak berovulasi. Desain studiadalah potong lintang menggunakan rekam medik pasien yang menjalani induksi ovulasi pada bulan Januari2011-Mei 2015. Sebanyak 143 perempuan yang tidak berovulasi dibagi dalam kelompok yang mendapatklomifen sitrat 50mg, klomifen sitrat 100mg, letrozol 2.5mg dan letrozol 5mg. Setiap kelompok mendapatobat induksi ovulasi antara hari ke-3 sampai hari ke-7 siklus haid. Pada hari ke-12 siklus haid dilakukanultrasonografi transvaginal untuk mengukur ketebalan endometrium dan jumlah folikel dominan. Sebanyak45 subyek (31,5%) mendapat klomifen sitrat 50mg, 29 subyek (20,3%) mendapat klomifen sitrat 100mg,23 subyek (16,1%) mendapat letrozol 2,5mg dan 46 subyek (32,2%) mendapat letrozol 5mg. Subyek yangmendapat letrozol memiliki endometrium yang lebih tebal dibandingkan kelompok klomifen sitrat (p<0,05).Dosis yang berbeda tidak berhubungan dengan ketebalan endometrium baik pada kelompok klomifen sitratmaupun letrozol. Kelompok yang mendapat letrozol lebih banyak memiliki gambaran morfologi endometriumtrilaminar. Tidak dijumpai perbedaan bermakna dalam jumlah folikel di antara semua kelompok. Disimpukanletrozol lebih efektif dibandingkan klomifen sitrat dalam hal ketebalan endometrium tetapi tidak untuk jumlahfolikel dominan. Kata kunci: klomifen sitrat, letrozol, induksi ovulasi, ketebalan endometrium, folikel dominan.