Antihyperglycemic Activity of Combination of Yakon Leaves (Smallanthus sonchifolius) Ethanolic Extract and Metformin in Mice Induced Alloxan
| Main Authors: | Kurniawati, Lidia, Ningsih, Dwi, Nopiyanti, Vivin |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | ind |
| Terbitan: |
Fakultas Farmasi Universitas Setia Budi
, 2014
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| Online Access: |
http://ejurnal.setiabudi.ac.id/ojs/index.php/farmasi-indonesia/article/view/68 http://ejurnal.setiabudi.ac.id/ojs/index.php/farmasi-indonesia/article/view/68/63 |
Daftar Isi:
- Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and related with abnormality metabolism of carbohydrate, lipid, and protein cause a decrease of insulin secretion or insulin sensitivity decrease or both. Yakon leaves is traditional medicinal plants that one of benefits could treat diabetes mellitus. The experiment was purpose to find antihyperglycemic activity of combination of yakon leaves ethanolic extract and metformin in mice induced alloxan. Test animals were divided in 6 groups each group consist of 5 mice. Groups I was given CMC 0,5%, group II was given metformin (65 mg/kg BB), group III was given yakon leaves ethanolic extract (840 mg/kg BB), group IV was given combination of yakon leaves ethanolic extract (420 mg/kg BB) and metformin (32,5 mg/ kg BB), group V was given combination of yakon leaves ethanolic extract (630 mg/kg BB) and metformin (16,25 mg/ kg BB). The treatment were given during 14 days, with measurement of glucose levels at 7 days and 14 days, then it was statistically tested by one way analysis of variance at 95% confidence continued with Tukey test. The result showed that the combination of yakon leaves ethanolic extract (630 mg/kg BB) and metformin (16,25 mg/ kg BB) was better than metformin or yakon leaves ethanolic extract.
- Diabetes melitus adalah gangguan metabolisme yang ditandai dengan hiperglikemia yang berhubungan dengan abnormalitas metabolisme karbohidrat, lemak, dan protein yang disebabkan oleh penurunan sekresi insulin atau penurunan sensitivitas insulin atau keduanya. Daun yakon (Smallanthus sonchifolius) merupakan tanaman obat tradisional yang salah satu manfaatnya dapat mengobati diabetes melitus. Penelitian ini bertujuan untuk mengetahui aktivitas antihiperglikemik kombinasi ekstrak daun yakon dan metformin pada mencit yang diinduksi aloksan. Hewan uji dibagi dalam 6 kelompok masing-masing kelompok terdiri dari 5 ekor mencit. Kelompok I CMC 0,5 %, kelompok II metformin (65 mg/kg BB), kelompok III ekstrak etanol daun yakon (840 mg/kg BB), kelompok IV kombinasi ekstrak etanol daun yakon (420 mg/kg BB) dan metformin (32,5 mg/kg BB), kelompok V kombinasi ekstrak etanol daun yakon (630 mg/kg BB) dan metformin (16,25 mg/kg BB). Perlakuan diberikan selama 14 hari, dengan pengukuran kadar gula darah pada hari ke-7 dan hari ke- 14, kemudian dilakukan uji statistik dengan analisis varian satu jalan dengan taraf kepercayaan 95% kemudian dilanjutkan uji Tukey. Hasil penelitian menunjukkan kombinasi ekstrak etanol daun yakon 630 mg/kg BB dan metformin 16,25 mg/ kg BB lebih baik dibanding sediaan tunggal metformin maupun ekstrak etanol daun yakon.