Optimation of Carbopol 941 And HPMC Combination in Gel Formulation of Cashew Leaves Extract by Simplex Lattice Design
| Main Author: | Kuncahyo, Ilham |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | ind |
| Terbitan: |
Fakultas Farmasi Universitas Setia Budi
, 2011
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| Online Access: |
http://ejurnal.setiabudi.ac.id/ojs/index.php/farmasi-indonesia/article/view/29 http://ejurnal.setiabudi.ac.id/ojs/index.php/farmasi-indonesia/article/view/29/23 |
Daftar Isi:
- Cashew leaves can be used as an antibacterial. The use of this cashew leaves in direct application can an unpractical, so it was made in the form of gel. This research was to get the gel optimum formula of the cashew leaves extract using two addition substances they were carbopol 941 and HPMC based on the simplex lattice design. The cashew leaves extract was obtained by maceration using ethanol 70% then it was evaporated to obtain concentrated extract. The optimum gel was based on simplex lattice design method with 2 components i.e. carbopol 941(C) and HPMC (H) used 3 formulations: formula I (100% C: 0% H), formula II (50% C: 50% H) and formula III (0% C: 100% H). Observation of physical properties included viscosity, the time of sticking and spreading ability, than it used to obtain SLD equation. The equation is used to make optimum gel formulation with the highest total respond of gelâ€TMs physical properties. The obtained data of simplex lattice design was compared to the result of real test by T-test. The result of the experiment showed that cashew leaves extract can be optimum formula of cashew leaves gel extract was obtained from the mixture of carbopol 941 60% - HPMC 40%. The result of t-Test of viscosity, adhesiveness and distribution showed that there was no significant difference between prediction and the result of real test.
- Daun jambu mete berkhasiat sebagai antibakteri. Penggunaan daun jambu mete secara langsung dinilai kurang praktis, sehingga dibuat sediaan gel. Penelitian ini bertujuan untuk mendapatkan formula optimum gel ekstrak daun jambu mete dari campuran carbopol 941 dan HPMC dengan menggunakan metode simplex lattice design. Ekstrak daun jambu mete diperoleh dengan metode maserasi menggunakan etanol 70%. Ekstrak yang diperoleh diuapkan hingga diperoleh ekstrak kental. Formula gel optimum berdasarkan simplex lattice design dengan 2 komponen yaitu: carbopol 941(C) dan HPMC (H), menggunakan 3 formula yaitu: formula I (100% C: 0% H), formula II (50% C: 50% H) dan formula III (0% C: 100% H). Sifat fisik yang diamati adalah viskositas, daya lekat dan daya sebar, yang selanjutnya digunakan untuk membuat persamaan SLD. Persamaan tersebut digunakan untuk menentukan formula optimum gel ekstrak daun jambu mete dari respon total sifat fisik gel yang paling besar. Hasil formula optimum yang diperoleh dari persamaan simplex latticedesign dibandingkan dengan hasil pengujian sesungguhnya dengan uji-t (T-test). Hasil penelitian menunjukkan bahwa formula optimum gel ekstrak daun jambu mete didapatkan pada campuran 60% carbopol 941 dan 40% HPMC. Hasil uji-t (T-test) viskositas, daya lekat dan daya sebar menunjukkan tidak berbeda signifikan antara prediksi dengan hasil percobaan sesungguhnya.