OPTIMATION OF AVICEL PH 101 AND CORN STACH MIXTURE IN TABLET MAKING OF MIMBA (Azadirachta indica A. Juss) LEAVES EXTRACT BY Simplex Lattice Design
| Main Author: | Kuncahyo, Ilham |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | ind |
| Terbitan: |
Fakultas Farmasi Universitas Setia Budi
, 2009
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| Online Access: |
http://ejurnal.setiabudi.ac.id/ojs/index.php/farmasi-indonesia/article/view/10 http://ejurnal.setiabudi.ac.id/ojs/index.php/farmasi-indonesia/article/view/10/4 |
Daftar Isi:
- Avicel PH 101 is an excipient in tablet making that can be used as diluent, binder, lubricant, and disintegrator. Avicel is not economically an advantage so that it needs to be combined with cheaper materials. Combination of Avicel PH 101 with corn starch is able to accelerate the disintegration time of the tablet. Mimba (Azadirachta indica A. Juss) leave is a traditional medicine that is used as anti-inflammation. The study was to find out the optimum proportion of Avicel PH 101 and corn starch mixture in tablet making of mimba leaves extract by simplex lattice design method. The extract of mimba leaves was obtained by maceration of mimba leaves powder with ethanol 70%. The obtained extract was evaporated until a thick extract was obtained. Tablet formulation was based on SLD method with excipients of Avicel PH 101 (A) and corn starch (B) i.e. F1 (100% A), F2 ( 50% A : 50% B), F3 (100% B). The tablets of mimba leaves extract were made by wet granulation. The equation was used to make tablets with total respond of the most optimum granules physical properties. The data of the physical properties of granules from optimum formula as calculation result based on SLD equation with the experiment result was analyzed using T-test. Tablets from optimum formula were physically tested including weight uniformity, hardness, friability and disintegration time. The result of theexperiment indicated that the mixture of 90% Avicel PH 101 – 10% corn starch produced an optimum result in granules physical properties and the obtained tablets of mimba leaves extract fulfilled tablet physical property test.
- Avicel PH 101 merupakan eksipien dalam pembuatan tablet yang dapat digunakan sebagai bahan pengisi, pengikat, pelicin dan penghancur. Avicel kurang menguntungkan dalam segi ekonomis sehingga perlu dikombinasikan dengan bahan yang lebih murah. Kombinasi Avicel PH 101 dengan pati jagung diharapkan dapat mempercepat waktu hancur tablet. Daun mimba (Azadirachta indica A. Juss) merupakan tanaman obat tradisional yang diantaranya digunakan sebagai anti inflamasi. Penelitian ini untuk mengetahui proporsi optimum campuran Avicel PH 101 dan pati jagung dalam formulasi tablet ekstrak daun mimba dengan metode simplex lattice design. Ekstrak daun mimba diperoleh dengan maserasi serbuk daun mimba menggunakan etanol 70%. Ekstrak yang diperoleh diuapkan sehingga diperoleh ekstrak kental. Formula tablet berdasarkan metode SLD dengan eksipien Avicel PH 101 (A) dan Pati jagung (B) yaitu : F1(100%A), F2(100%B), F3 (50%A:50%B). Tablet ekstrak daun mimba dibuat secara granulasi basah. Granul diuji kecepatan alir, kompaktibilitas dan waktu hancur untuk mendapatkan persamaan SLD. Persamaan tersebut digunakan untuk membuat tablet dengan respon total sifat fisik granul yang paling optimum. Data sifat fisik granul formula optimum hasil perhitungan berdasarkan persamaan SLD dengan hasil pengujian sesungguhnya dianalisis menggunakan uji t. Tablet formula optimum diuji sifat fisiknya yang meliputi : keseragaman bobot, kekerasan, kerapuhan dan waktu hancur tablet. Hasil penelitian menunjukkan campuran 90% Avicel PH 101 - 10%pati jagung memberikan hasil yang optimal pada sifat fisik granul dan tablet ekstrak daun mimba yang dihasilkan memenuhi uji sifat fisik tablet.