UJI AKTIVITAS DIURETIK EKSTRAK ETANOL DAUN PETAI (Parkia speciosaHassk) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR
Daftar Isi:
- Parkia speciosa leaves empirically used to heal diabetes mellitus and hypertension, one of the group of hypertension drugs is diuretic. Parkia speciosa leaves contained flavonoid compounds that have been widely studied as a diuretic agent. The total compounds of Flavonoid in Parkia speciosa Hassk leaves was 40,51 mg/g extract. This research used wistar male rats and divided into 5 groups, consisting of normal control group (Sodium CMC 1% 2 mL/200 gBW), positive control g roup (furosemide 20 mg/kgBW), and treatment groups I III : ethanolic extract of Parkia speciosa Hassk leaves dose of 100, 250, and 500 mg/kgBW. Test animals were not given the early treatment, only acclitimization for the first one week. The volume of urin e was measured after the treatment every 1 hour for 6 hours. Diuretic activity did in the metabolic cage that can accommodate the urine of rats. The volume of urine was measured and analyzed qualitatively of sodium, potassium, and cloride ions. Furosemide as a positive control produced the most volume of urine, 3.685 ml. Ethanolic extract of Parkia speciosa Hassk leaves 500mg/BW dose produced 3.125 ml total volume of urine and had the highest diuretic activity, 69.78%, than the other dose of ethanolic extra ct. ED 50 value was 327,02 mg/kgBW. Furosemide and ethanolic extract of Parkia speciosa Hassk leaves showed the positive result of urine that contained sodium, potassium, and chloride ions. Based on these results, it was concluded that ethanolic extract of Parkia speciosa leaves had a diuretic activity with a similar mechanism of action of furosemide.