EFEK PEMBERIAN EKSTRAK ETANOL DAUN MATOA (Pometia pinnata) SEBAGAI HEPATOPROTEKTOR TERHADAP GAMBARAN HISTOPATOLOGI HEPAR TIKUS JANTAN YANG DIINDUKSI PARASETAMOL
Daftar Isi:
- A research of hepatoprotector activity from matoa’s leaf (Pometia pinnata) ethanolic extract on male white rat induced by paracetamol has been done. This study aimed to find out any hepatoprotector activity from matoa’s leaf ethanolic extract based on measurement of SGPT and SGOT levels and also histopathology pictures of rats’ liver. The experiment was done on 24 male white Wistar rats that devided into 6 groups of treatment. Rats in group I as normal control were only given 1% sodium CMC, rats in group II as negative control were given paracetamol 2 g/kgBB, rats in group III as positive control were given N-acetylcysteine, and rats in groups IV, V, and VI as test group was given extract of 125, 250, 500 mg/kgBB doses. The average of SGPT on normal, negative, positive, and test group of 125, 250, and 500 mg/kgBB doses were 81.17 ± 10.07; 285.90 ± 128.31; 95.57 ± 3.01; 208.0 ± 62.0; 156.76 ± 26.15; 98.43 ± 18.58 U/L. While the average of SGOT on normal, negative, positive, test group of 125, 250, and 500 mg/kgBB doses were 175.14 ± 8.07; 331.23 ± 64.79; 192.9 ± 8.52; 279.4 ± 22.50; 231.26 ± 36.99; 198.42 ± 12.66 U/L. Respectively the result indicated that matoa’s leaf ethanolic extract significantly (p<0.05) lowered SGPT and SGOT levels compared to control negative group and influenced the histopathology pictures of paracetamol-induced rats’ liver. Dose of 500 mg/kgBB gave better hepatoprotector activity than doses of 125 and 250 mg/kgBB. Hepatoprotector activity on this group was shown by the reduction of SGPT and SGOT levels and also normal hepatic histopathology without degeneration of hepatocyte, bleeding of liver tissue or necrosis cell although toxic dose of paracetamol has been given