OPTIMASI DAN KARAKTERISASI SOLID LIPID NANOPARTIKEL AZITROMISIN DENGAN VARIASI KONSENTRASI TWEEN-80 SEBAGAI SURFAKTAN, SUHU PEMBUATAN, DAN KECEPATAN PENGADUKAN
Daftar Isi:
- Azithromycin is an antibiotic used for upper respiratory tract infection (URIs). Formulation of solid lipid nanoparticle (SLN) is purpose to improving the solubility of non-polar azithromycin. The SLN preparations have been formulated using tween-80, manufacture temperature, and stirring rate as factors with 23 factorial designs on the design expert® program. The result of analysis of EE percent, particle size, PDI, and zeta potential yielded result of 64,333%, 796,7nm; 0.578; and -7.3 mV. Stability testing with thermodynamic method with temperature 4 and 40oC for 6 cycles showed optimum solid lipid nanoparticle formula more stable than pure azithromycin. The optimum formula results are characterized using several parameters: particle morphology, particle distribution and potential zeta, dissolution rate in vitro, FTIR interaction study, and viscosity. Percentage decrease of SLN azitromisin until 6th cycle reach 9,32 %. The results of %disolution for 6 hours SLN, tablet, and pure azitromisin respectively, 98,3079; 52,9437; and 18,06011%. Based on research result, azithromycin can be formulated in solid lipid nanoparticle dosage form with good quality. The effect of factor composition and interaction was observed based on EE response test results, stability, and SLN pH. Test results were analyzed using DX®10 to obtain the optimum formula with the concentration of tween-80 0,5ml, making temperature of 60oC, and stirring speed 1500 rpm. The tween-80 factor can improve stability but can decrease percent EE and pH of azithromycin SLN preparations. The temperature factor of the manufacture and the speed of stirring may increase the pH and EE percent response value but decrease the stability of the preparation. Basedon the research, it was conclude that azitromisin can be formulated into solid lipid nanoparticle