HUBUNGAN ANTARA KADAR BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) DENGAN TINGKAT KECERDASAN PADA ANAK SEKOLAH DASAR DI DAERAH ENDEMIK MALARIA KABUPATEN SELUMA TAHUN 2019
Daftar Isi:
- BDNF is a group of neurotrophins that contribute greatly to the learning process and memory. BDNF is closely related to cognitive functions, including the formation of memory, learning processes and behavior. This study aim was to analyze the relationship between levels of Brain Derived Neurotrophic Factor (BDNF) with the level of intelligence in elementary school children in malaria endemic areas of Seluma Regency. Methods: This study was an observational analytic with cross sectional design, this study involved the 75 participants of elementary school children aged 9-12 years, held in April 2019. Venous blood sampling was performed to measure BDNF levels using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The level of intelligence is measured using the Culture Fair Intelligence Test (CFIT). Physical activity was assessed by Physical Activity Questionnaire for Older Children (PAQ-C). Data on sample characteristics was obtained through interviews by questionnaires. Then the data were analyzed using Chi square test and logistic regression. The results of BDNF measurements found 31 children (41.3%) had BDNF levels below the average (<3411.205ng/mL). The results of measuring the level of intelligence found that 59 children (78.7%) had a level of intelligence below the average. Statistics test results obtained that BDNF levels (p= 0.019), nutritional status (p= 0.037), physical activity (p= 0.031) had a significant relationship with intelligence level. Based on probability model, it is found that elementary school children who have BDNF levels below the average have a probability of intelligence levels below the average of 42%. Conclusions : Elementary school children in malaria endemic areas who had a BDNF level below an average of 5.3 times the risk of having a level of intelligence below the average compared to children with BDNF levels equal to or above the average after being controlled with variables of nutritional status and physical activity. Key word : BDNF; endemic malaria area; intelligence; school children Citation : 100 (1989-2018)