INKORPORASI MINYAK ATSIRI PEPPERMINT (Mentha pipeita) DALAM PATCH BERBASIS POLIMER HPMC-KITOSAN
Daftar Isi:
- This study is aimed to incorporate peppermint essential oil (Mentha piperita) into patch. Patches were incorporated peppermint essential oil (Mentha piperita) were tested for their ability to inhibit the activity of bacteria Staphylococcus aureus and were analyzed for physical properties. Patches were prepared in several formulas i.e. the addition of essential oils with volume ratio 0 μL/mL (F I), 32 μL/mL (F II), 48 μL/mL (F III), 64 μL/mL (F IV), and 80 μL/mL (F V) of the total polymer volume ("v" ⁄"v" ). The patch obtained was tested for antibacterial activity and physical properties. The results showed that the five patches had variety of weight, thickness and folding endurance comply with the standard, as well as good swelling index. Formula V contained 80 μL/mL ("v" ⁄"v" ) of peppermint essential oil was chosen as the best formula because it could inhibited Staphylococcus aureus in the active category with inhibitory zone values of 14,37 ± 0,92 mm which expanded at 5th minute with an average weight value of 0.0502 ± 0.0007 g and an average value of thickness 0.18 ± 0.01 mm and fold resistance value >300 times. Antibacterial compounds within peppermint essential oils detected by GC-MS were l-Menthone, Isomenthone, p-Menthan-1-ol, Menthol, D-limonene, Isopulegol, Isomenthol acetate, Pulegone, Isocaryophyllene, dan β-caryophyllene. The result of this work verify that peppermint essential oils incorporation into patch shows antibacterial activity and good physical properties.