KORELASI ANTARA KADAR C-REAKTIF PROTEIN DENGAN SKOR MEX-SLEDAI PADA PENDERITA LUPUS ERITEMATOSUS SISTEMIK DI PALEMBANG
Daftar Isi:
- Background: Systemic lupus erythematosus (SLE) is an autoimmune disease caused by the immune system which mistakenly attacks healthy tissue. This can affect the skin, joints, kidneys, brain, and other organs. Every year more than 100,000 case of SLE are found in the world, economic and geographic factors do not affect the distribution of disease. SLE can be found at all ages, but most at productive age, which is 15-40 years. Women are more affected than men, which ranges from (5.5-9): 1. In patients with SLE, there are disturbances in the mechanism of immune regulation such as disruption of cleaning apoptotic cells and immune complexes which are important contributors in the development of this disease. Methods: This study is an analytical observational study conducted using cross sectional design study. Research subjects were 36 SLE patients who met the inclusion and exclusion criteria. Results: Respondents consisted of 34 (94.4%) female respondents and 2 (5.6%) male respondents. Subjects aged 16-21 years dominated this study with a 25% presentation. Respondents consisted of 26 (72.2%) respondents with CRP results <5, 2 (5.6%) respondents with 10 results, and for CRP results 7,8,11,15,25,30,98,104 (2,8 %) 1 respondent each. Obtained research subjects with 15 (41.7%) research subjects with a score of 3, 9 (25%) research subjects with a score of 4, 6 (16.7%) research subjects with a score of 5, 3 (8.3%) research subjects with a score of 6, 2 (5.6%) research subjects with a score of 7, and 1 (2.8%) research subjects with a score of 8. In this study the anxiety level variable does not have a significant correlation (p <0.05) between scores MEX-SLEDAI with CRP levels. Conclusion: The correlation coefficient r = 0.124 between MEX-SLEDAI scores with CRP levels shows a positive correlation and very weak strength. Thus, these two variables cannot be a predictor factor in LES patients.