RED CELL DISTRIBUTION WIDTH (RDW) SEBAGAI PENUNJANG DIAGNOSIS SEPSIS NEONATORUM PADA NEONATUS USIA GESTASI 34-42 MINGGU
Daftar Isi:
- Introduction: Neonatal sepsis is still an emergency because delayed treatment can be fatal, whereas the diagnosis is challenging because of the unspesific clinical manifestation. Bacterial culture is the gold standard for the diagnosis of neonatal sepsis but it takes several days to get the result which often come out as negative. This study aims to determine the diagnostic value of RDW to support the diagnosis of neonatal sepsis in 34-42 gestational age neonates. Methods: This cross-sectional diagnostic study uses secondary data obtained from Medical Record Installation and Clinical Pathology Laboratory of Dr. Mohammad Hoesin General Hospital in Palembang from the time period June 2017 – June 2019. One hundred and thirty-four medical records of suspected infection neonates is statistically analyzed using MedCalc Version 19 to determine the cut-off point and diagnostic value of RDW in the diagnosis of neonatal sepsis. Results: One hundred and thirty-four subjects consisting 32 septic neonates (23,9%) and 102 non-septic neonates (76,1%) were reviewed. Most of them are males (80/134) and preterm (73/134) with normal birthweight (99/134). At the cut-off point of >16,2%, RDW value is significantly able to predict neonatal sepsis (p = 0,000, p < α) with prediction power (AUC) of 0,780 (fair). The diagnostic values are sensitivity 84,37%, specificity 57,84%, positive predictive value 38,57%, negative predictive value 92,19%, positive likelihood ratio 2,00, negative likelihood ratio 0,27, and accuracy 64,18%. Conclusion: Red cell distribution width value can be used as diagnostic marker to support the diagnosis of neonatal sepsis in 34-42 gestational age neonates.