Plagiarism_Legiran_Bone mass regulation of leptin and postmenopausal osteoporosis with obesity

Main Author: Legiran, Legiran
Format: Lainnya NonPeerReviewed Book
Bahasa: eng
Terbitan: Clinical Cases in Mineral and Bone Metabolism , 2012
Subjects:
Online Access: http://repository.unsri.ac.id/19953/1/Plagiat_Legiran_Bone%20Leptin.pdf
http://repository.unsri.ac.id/19953/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536002/pdf/0635_7_bone_legiran.pdf
ctrlnum 19953
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><relation>http://repository.unsri.ac.id/19953/</relation><title>Plagiarism_Legiran_Bone mass regulation of leptin and postmenopausal osteoporosis with obesity</title><creator>Legiran, Legiran</creator><subject>Results of Ithenticate Plagiarism and Similarity Checker</subject><description>Background. Leptin has been known to play a role in weight regulation through food intake and energy expenditure. Leptin also has an important role in bone metabolism. The role of leptin is determined by leptin receptors, either central or peripheral to the bones. Design. We discuss the role of leptin on bone and molecular genetics of osteoporosis in postmenopausal obese women. Results. The role of leptin in bone preserves bone mineral density (BMD) through increased OPG levels leading to bind RANKL, resulting in reducing osteoclast activity. The estrogen role on bone is also mediated by RANKL and OPG. In postmenopausal women who have estrogen deficiency, it increases the rate of RANKL, which increases osteoclastogenesis. Obese individuals who have a high level of leptin will be effected by bone protection. Conclusion. There are similarities in the mechanism between estrogen and leptin in influencing the process of bone remodeling. It may be considered that the role of estrogen can be replaced by leptin. Molecular genetic aspects that play a role in bone remodeling, such as leptin, leptin receptors, cytokines (e.g. RANK, RANKL, and OPG), require further study to be useful, especially regarding osteoporosis therapy based on genetic analysis.</description><publisher>Clinical Cases in Mineral and Bone Metabolism</publisher><date>2012-12-20</date><type>Other:Other</type><type>PeerReview:NonPeerReviewed</type><type>Book:Book</type><language>eng</language><identifier>http://repository.unsri.ac.id/19953/1/Plagiat_Legiran_Bone%20Leptin.pdf</identifier><identifier> Legiran, Legiran (2012) Plagiarism_Legiran_Bone mass regulation of leptin and postmenopausal osteoporosis with obesity. Clinical Cases in Mineral and Bone Metabolism. </identifier><relation>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536002/pdf/0635_7_bone_legiran.pdf</relation><relation>Vol. 9 No. 3 (2012)</relation><recordID>19953</recordID></dc>
language eng
format Other:Other
Other
PeerReview:NonPeerReviewed
PeerReview
Book:Book
Book
author Legiran, Legiran
title Plagiarism_Legiran_Bone mass regulation of leptin and postmenopausal osteoporosis with obesity
publisher Clinical Cases in Mineral and Bone Metabolism
publishDate 2012
topic Results of Ithenticate Plagiarism and Similarity Checker
url http://repository.unsri.ac.id/19953/1/Plagiat_Legiran_Bone%20Leptin.pdf
http://repository.unsri.ac.id/19953/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536002/pdf/0635_7_bone_legiran.pdf
contents Background. Leptin has been known to play a role in weight regulation through food intake and energy expenditure. Leptin also has an important role in bone metabolism. The role of leptin is determined by leptin receptors, either central or peripheral to the bones. Design. We discuss the role of leptin on bone and molecular genetics of osteoporosis in postmenopausal obese women. Results. The role of leptin in bone preserves bone mineral density (BMD) through increased OPG levels leading to bind RANKL, resulting in reducing osteoclast activity. The estrogen role on bone is also mediated by RANKL and OPG. In postmenopausal women who have estrogen deficiency, it increases the rate of RANKL, which increases osteoclastogenesis. Obese individuals who have a high level of leptin will be effected by bone protection. Conclusion. There are similarities in the mechanism between estrogen and leptin in influencing the process of bone remodeling. It may be considered that the role of estrogen can be replaced by leptin. Molecular genetic aspects that play a role in bone remodeling, such as leptin, leptin receptors, cytokines (e.g. RANK, RANKL, and OPG), require further study to be useful, especially regarding osteoporosis therapy based on genetic analysis.
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