Maternal carbamazepine alters fetal neuroendocrine-cytokines axis
| Main Author: | R. G., Ahmed |
|---|---|
| Format: | Dataset |
| Terbitan: |
Mendeley
, 2017
|
| Subjects: | |
| Online Access: |
https:/data.mendeley.com/datasets/rt2h2mk9pf |
| ctrlnum |
0.17632-rt2h2mk9pf.1 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc><creator>R. G., Ahmed</creator><title>Maternal carbamazepine alters fetal neuroendocrine-cytokines axis</title><publisher>Mendeley</publisher><description>This study detected the impact of maternal carbamazepine (CBZ) on the fetal neuroendocrine-cytokines
axis. 25 or 50 mg/kg of CBZ was intraperitoneally administrated to pregnant albino rats from the
gestation day (GD) 1 to 20. Both administrations of CBZ caused a hypothyroidism in dams and fetuses
whereas the decreases in serum thyroxine (T4) and triiodothyronine (T3) and increases in serum
thyrotropin (TSH) levels were highly significant (LSD; P < 0.01) at GD 20 compared to untreated control
dams. Also, both administrations had undesirable impacts on the maternofetal body weight, litter
weight, survival of dams and fetuses, and their food consumption in comparison to the corresponding
control. These administrations also elicited a reduction in fetal serum growth hormone (GH), interferon-
g (IFNg), interleukins (IL-2 & 4) and prostaglandin E2 (PGE2) levels. Also, the elevation in fetal serum
tumor necrosis factor-alpha (TNFa), transforming growth factor-beta (TGFb), and interleukins (IL-1b &
17) levels was observed at embryonic day (ED) 20. Moreover, there were a cellular fragmentation,
distortion, hyperemia, oedema and vacuolation in the fetal cerebellar cortex due to both maternal
administrations. These developmental changes were dose-dependent. These novel results suggest that
CBZ may act as a developmental immunoneuroendocrine disruptor.</description><subject>Brain Development</subject><type>Other:Dataset</type><identifier>10.17632/rt2h2mk9pf.1</identifier><rights>Creative Commons Attribution 4.0 International</rights><rights>http://creativecommons.org/licenses/by/4.0</rights><relation>https:/data.mendeley.com/datasets/rt2h2mk9pf</relation><date>2017-09-21T11:23:42Z</date><recordID>0.17632-rt2h2mk9pf.1</recordID></dc>
|
| format |
Other:Dataset Other |
| author |
R. G., Ahmed |
| title |
Maternal carbamazepine alters fetal neuroendocrine-cytokines axis |
| publisher |
Mendeley |
| publishDate |
2017 |
| topic |
Brain Development |
| url |
https:/data.mendeley.com/datasets/rt2h2mk9pf |
| contents |
This study detected the impact of maternal carbamazepine (CBZ) on the fetal neuroendocrine-cytokines
axis. 25 or 50 mg/kg of CBZ was intraperitoneally administrated to pregnant albino rats from the
gestation day (GD) 1 to 20. Both administrations of CBZ caused a hypothyroidism in dams and fetuses
whereas the decreases in serum thyroxine (T4) and triiodothyronine (T3) and increases in serum
thyrotropin (TSH) levels were highly significant (LSD; P < 0.01) at GD 20 compared to untreated control
dams. Also, both administrations had undesirable impacts on the maternofetal body weight, litter
weight, survival of dams and fetuses, and their food consumption in comparison to the corresponding
control. These administrations also elicited a reduction in fetal serum growth hormone (GH), interferon-
g (IFNg), interleukins (IL-2 & 4) and prostaglandin E2 (PGE2) levels. Also, the elevation in fetal serum
tumor necrosis factor-alpha (TNFa), transforming growth factor-beta (TGFb), and interleukins (IL-1b &
17) levels was observed at embryonic day (ED) 20. Moreover, there were a cellular fragmentation,
distortion, hyperemia, oedema and vacuolation in the fetal cerebellar cortex due to both maternal
administrations. These developmental changes were dose-dependent. These novel results suggest that
CBZ may act as a developmental immunoneuroendocrine disruptor. |
| id |
IOS7969.0.17632-rt2h2mk9pf.1 |
| institution |
Universitas Islam Indragiri |
| affiliation |
onesearch.perpusnas.go.id |
| institution_id |
804 |
| institution_type |
library:university library |
| library |
Teknologi Pangan UNISI |
| library_id |
2816 |
| collection |
Artikel mulono |
| repository_id |
7969 |
| city |
INDRAGIRI HILIR |
| province |
RIAU |
| shared_to_ipusnas_str |
1 |
| repoId |
IOS7969 |
| first_indexed |
2020-04-08T08:11:09Z |
| last_indexed |
2020-04-08T08:11:09Z |
| recordtype |
dc |
| _version_ |
1686587387906359296 |
| score |
17.538404 |