2018 JACC CI (Aptoglobin and STEMI detcetd by CMR)
| Main Author: | Pontone, Gianluca |
|---|---|
| Format: | Dataset |
| Terbitan: |
Mendeley
, 2019
|
| Subjects: | |
| Online Access: |
https:/data.mendeley.com/datasets/gpmp2m8yn2 |
| ctrlnum |
0.17632-gpmp2m8yn2.1 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc><creator>Pontone, Gianluca</creator><title>2018 JACC CI (Aptoglobin and STEMI detcetd by CMR)</title><publisher>Mendeley</publisher><description>OBJECTIVES This study aimed to evaluate the correlation between different haptoglobin (Hp) phenotypes and
myocardial infarction characteristics as detected by cardiac magnetic resonance (CMR) in consecutive patients after
ST-segment elevation myocardial infarction (STEMI).
BACKGROUND Hp is a plasma protein that prevents iron-mediated oxidative tissue damage. CMR has emerged as the
gold standard technique to detect left ventricular ejection fraction (LVEF), extent of scar with late gadolinium
enhancement (LGE) technique, microvascular obstruction (MVO), and myocardial hemorrhage (MH) in patients with
STEMI treated by primary percutaneous coronary intervention (pPCI).
METHODS One hundred forty-five consecutive STEMI patients (mean age 62.2 10.3 years; 78% men) were prospectively
enrolled and underwent Hp phenotyping and CMR assessment within 1 week after STEMI.
RESULTS CMR showed an area at risk (AAR) involving 26.6 19.1% of left ventricular (LV) mass with a late LGE extent
of 15.2 13.1% of LV mass. MVO and MH occurred in 38 (26%) and 12 (8%) patients, respectively. Hp phenotypes 1-1, 2-
1, 2-2 were observed in 15 (10%), 62 (43%), and 68 (47%), respectively. Multivariable analysis demonstrated that body
mass index, Hp2-2, diabetes, and peak troponin I were independent predictors of MVO with Hp2-2 associated with the
highest odds ratio (OR) (OR: 5.5 [95% confidence interval [CI]: 2.1 to 14.3; p < 0.001]). Hp2-2 significantly predicted
both the presence (area under the curve [AUC]: 0.63 [95% CI: 0.53 to 0.72; p ¼ 0.008]) and extent of MVO (AUC: 0.63
[95% CI: 0.54 to 0.72; p ¼ 0.007]).
CONCLUSIONS Hp phenotype is an independent predictor of MVO. Therefore, Hp phenotyping could be used for risk
stratification and may be useful in assessing new therapies to reduce myocardial reperfusion injury in patients with STEMI.</description><subject>Cardiology</subject><type>Other:Dataset</type><identifier>10.17632/gpmp2m8yn2.1</identifier><rights>Creative Commons Attribution 4.0 International</rights><rights>http://creativecommons.org/licenses/by/4.0</rights><relation>https:/data.mendeley.com/datasets/gpmp2m8yn2</relation><date>2019-09-15T18:55:16Z</date><recordID>0.17632-gpmp2m8yn2.1</recordID></dc>
|
| format |
Other:Dataset Other |
| author |
Pontone, Gianluca |
| title |
2018 JACC CI (Aptoglobin and STEMI detcetd by CMR) |
| publisher |
Mendeley |
| publishDate |
2019 |
| topic |
Cardiology |
| url |
https:/data.mendeley.com/datasets/gpmp2m8yn2 |
| contents |
OBJECTIVES This study aimed to evaluate the correlation between different haptoglobin (Hp) phenotypes and
myocardial infarction characteristics as detected by cardiac magnetic resonance (CMR) in consecutive patients after
ST-segment elevation myocardial infarction (STEMI).
BACKGROUND Hp is a plasma protein that prevents iron-mediated oxidative tissue damage. CMR has emerged as the
gold standard technique to detect left ventricular ejection fraction (LVEF), extent of scar with late gadolinium
enhancement (LGE) technique, microvascular obstruction (MVO), and myocardial hemorrhage (MH) in patients with
STEMI treated by primary percutaneous coronary intervention (pPCI).
METHODS One hundred forty-five consecutive STEMI patients (mean age 62.2 10.3 years; 78% men) were prospectively
enrolled and underwent Hp phenotyping and CMR assessment within 1 week after STEMI.
RESULTS CMR showed an area at risk (AAR) involving 26.6 19.1% of left ventricular (LV) mass with a late LGE extent
of 15.2 13.1% of LV mass. MVO and MH occurred in 38 (26%) and 12 (8%) patients, respectively. Hp phenotypes 1-1, 2-
1, 2-2 were observed in 15 (10%), 62 (43%), and 68 (47%), respectively. Multivariable analysis demonstrated that body
mass index, Hp2-2, diabetes, and peak troponin I were independent predictors of MVO with Hp2-2 associated with the
highest odds ratio (OR) (OR: 5.5 [95% confidence interval [CI]: 2.1 to 14.3; p < 0.001]). Hp2-2 significantly predicted
both the presence (area under the curve [AUC]: 0.63 [95% CI: 0.53 to 0.72; p 1⁄4 0.008]) and extent of MVO (AUC: 0.63
[95% CI: 0.54 to 0.72; p 1⁄4 0.007]).
CONCLUSIONS Hp phenotype is an independent predictor of MVO. Therefore, Hp phenotyping could be used for risk
stratification and may be useful in assessing new therapies to reduce myocardial reperfusion injury in patients with STEMI. |
| id |
IOS7969.0.17632-gpmp2m8yn2.1 |
| institution |
Universitas Islam Indragiri |
| affiliation |
onesearch.perpusnas.go.id |
| institution_id |
804 |
| institution_type |
library:university library |
| library |
Teknologi Pangan UNISI |
| library_id |
2816 |
| collection |
Artikel mulono |
| repository_id |
7969 |
| city |
INDRAGIRI HILIR |
| province |
RIAU |
| shared_to_ipusnas_str |
1 |
| repoId |
IOS7969 |
| first_indexed |
2020-04-08T08:22:48Z |
| last_indexed |
2020-04-08T08:22:48Z |
| recordtype |
dc |
| _version_ |
1686587561251700736 |
| score |
17.538404 |