Data for: Substituent effect of N-benzylated gramine derivatives that up-regulate the PP2A-leaded phosphatase activity and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer’s disease
| Main Author: | Cristóbal, de los Ríos |
|---|---|
| Other Authors: | Viejo, Lucia, Gonzalez, Dorleta, Arribas, Raquel L, Lajarin-Cuesta, Rocio |
| Format: | Dataset |
| Terbitan: |
Mendeley
, 2018
|
| Subjects: | |
| Online Access: |
https:/data.mendeley.com/datasets/9n2kdhr4nk |
| ctrlnum |
0.17632-9n2kdhr4nk.1 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc><creator>Cristóbal, de los Ríos</creator><title>Data for: Substituent effect of N-benzylated gramine derivatives that up-regulate the PP2A-leaded phosphatase activity and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer’s disease</title><publisher>Mendeley</publisher><description>Compounds of the general formula CC1=CC2=C(C=C1)N(CC1=CC=CC=C1)C=C2CN1CCCCC1 (comp. 2) with different substituents at the pending aromatic ring (comp. 9 = p-Me; comp. 10 = m-Cl; comp. 11 = p-Cl; comp. 12 = p-F; comp. 13 = o-NO2; comp. 14 = m-NO2), were tested as voltage-gated Ca2+ channels blockers and protein phosphatase 2A-activating drugs. The mutual effect on these two biological targets closely implicated in the Alzheimer's disease progression induced neuroprotection in a model of Tau hyperphosphorylation.</description><subject>Pharmaceutical Chemistry</subject><contributor>Viejo, Lucia</contributor><contributor>Gonzalez, Dorleta</contributor><contributor>Arribas, Raquel L</contributor><contributor>Lajarin-Cuesta, Rocio</contributor><type>Other:Dataset</type><identifier>10.17632/9n2kdhr4nk.1</identifier><rights>Creative Commons Attribution 4.0 International</rights><rights>http://creativecommons.org/licenses/by/4.0</rights><relation>https:/data.mendeley.com/datasets/9n2kdhr4nk</relation><date>2018-04-12T12:20:42Z</date><recordID>0.17632-9n2kdhr4nk.1</recordID></dc>
|
| format |
Other:Dataset Other |
| author |
Cristóbal, de los Ríos |
| author2 |
Viejo, Lucia Gonzalez, Dorleta Arribas, Raquel L Lajarin-Cuesta, Rocio |
| title |
Data for: Substituent effect of N-benzylated gramine derivatives that up-regulate the PP2A-leaded phosphatase activity and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer’s disease |
| publisher |
Mendeley |
| publishDate |
2018 |
| topic |
Pharmaceutical Chemistry |
| url |
https:/data.mendeley.com/datasets/9n2kdhr4nk |
| contents |
Compounds of the general formula CC1=CC2=C(C=C1)N(CC1=CC=CC=C1)C=C2CN1CCCCC1 (comp. 2) with different substituents at the pending aromatic ring (comp. 9 = p-Me; comp. 10 = m-Cl; comp. 11 = p-Cl; comp. 12 = p-F; comp. 13 = o-NO2; comp. 14 = m-NO2), were tested as voltage-gated Ca2+ channels blockers and protein phosphatase 2A-activating drugs. The mutual effect on these two biological targets closely implicated in the Alzheimer's disease progression induced neuroprotection in a model of Tau hyperphosphorylation. |
| id |
IOS7969.0.17632-9n2kdhr4nk.1 |
| institution |
Universitas Islam Indragiri |
| affiliation |
onesearch.perpusnas.go.id |
| institution_id |
804 |
| institution_type |
library:university library |
| library |
Teknologi Pangan UNISI |
| library_id |
2816 |
| collection |
Artikel mulono |
| repository_id |
7969 |
| city |
INDRAGIRI HILIR |
| province |
RIAU |
| shared_to_ipusnas_str |
1 |
| repoId |
IOS7969 |
| first_indexed |
2020-04-08T08:19:21Z |
| last_indexed |
2020-04-08T08:19:21Z |
| recordtype |
dc |
| _version_ |
1686587543126016000 |
| score |
17.538404 |