The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers
| Main Author: | kiran, Shashi |
|---|---|
| Other Authors: | Dar, Ashraf , Singh, Samrendra Kumar , Lee, Kyung Yong, Dutta, Anindya |
| Format: | Dataset |
| Terbitan: |
Mendeley
, 2018
|
| Subjects: | |
| Online Access: |
https:/data.mendeley.com/datasets/5tk7md7rxz |
| ctrlnum |
0.17632-5tk7md7rxz.1 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc><creator>kiran, Shashi</creator><title>The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers</title><publisher>Mendeley</publisher><description>The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers.
High-risk Human Papilloma Viruses (HPV) cause cervical, anal and oropharyngeal cancers, unlike the low-risk HPVs, which cause benign lesions. E6 oncoproteins from the high-risk strains are essential for cell proliferation and transformation in HPV induced cancers. We report that a cellular deubiquitinase, USP46 is selectively recruited by the E6 of high-risk, but not low-risk, HPV to deubiqutinate and stabilize Cdt2/DTL. Stabilization of Cdt2, a component of the CRL4Cdt2 E3 ubiquitin ligase, limits the level of Set8, an epigenetic writer, and promotes cell-proliferation. USP46 is essential for the proliferation of HPV-transformed cells, but not of cells without HPV. Cdt2 is elevated in human cervical cancers and knockdown of USP46 inhibits HPV-transformed tumor growth in xenografts. Recruitment of a cellular deubiquitinase to stabilize key cellular proteins is an important activity of oncogenic E6, and the importance of E6-USP46-Cdt2-Set8 pathway in HPV-induced cancers makes USP46 a target for the therapy of such cancers.</description><subject>Cervical Cancer</subject><subject>Human Papillomavirus</subject><contributor>Dar, Ashraf </contributor><contributor>Singh, Samrendra Kumar </contributor><contributor>Lee, Kyung Yong</contributor><contributor>Dutta, Anindya</contributor><type>Other:Dataset</type><identifier>10.17632/5tk7md7rxz.1</identifier><rights>Creative Commons Attribution 4.0 International</rights><rights>http://creativecommons.org/licenses/by/4.0</rights><relation>https:/data.mendeley.com/datasets/5tk7md7rxz</relation><date>2018-11-10T14:32:53Z</date><recordID>0.17632-5tk7md7rxz.1</recordID></dc>
|
| format |
Other:Dataset Other |
| author |
kiran, Shashi |
| author2 |
Dar, Ashraf Singh, Samrendra Kumar Lee, Kyung Yong Dutta, Anindya |
| title |
The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers |
| publisher |
Mendeley |
| publishDate |
2018 |
| topic |
Cervical Cancer Human Papillomavirus |
| url |
https:/data.mendeley.com/datasets/5tk7md7rxz |
| contents |
The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers.
High-risk Human Papilloma Viruses (HPV) cause cervical, anal and oropharyngeal cancers, unlike the low-risk HPVs, which cause benign lesions. E6 oncoproteins from the high-risk strains are essential for cell proliferation and transformation in HPV induced cancers. We report that a cellular deubiquitinase, USP46 is selectively recruited by the E6 of high-risk, but not low-risk, HPV to deubiqutinate and stabilize Cdt2/DTL. Stabilization of Cdt2, a component of the CRL4Cdt2 E3 ubiquitin ligase, limits the level of Set8, an epigenetic writer, and promotes cell-proliferation. USP46 is essential for the proliferation of HPV-transformed cells, but not of cells without HPV. Cdt2 is elevated in human cervical cancers and knockdown of USP46 inhibits HPV-transformed tumor growth in xenografts. Recruitment of a cellular deubiquitinase to stabilize key cellular proteins is an important activity of oncogenic E6, and the importance of E6-USP46-Cdt2-Set8 pathway in HPV-induced cancers makes USP46 a target for the therapy of such cancers. |
| id |
IOS7969.0.17632-5tk7md7rxz.1 |
| institution |
Universitas Islam Indragiri |
| affiliation |
onesearch.perpusnas.go.id |
| institution_id |
804 |
| institution_type |
library:university library |
| library |
Teknologi Pangan UNISI |
| library_id |
2816 |
| collection |
Artikel mulono |
| repository_id |
7969 |
| city |
INDRAGIRI HILIR |
| province |
RIAU |
| shared_to_ipusnas_str |
1 |
| repoId |
IOS7969 |
| first_indexed |
2020-04-08T08:13:20Z |
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2020-04-08T08:13:20Z |
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dc |
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1686587399451181056 |
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17.538404 |