تقدير الجهد ضد الفطريات لـ Morganella morganii وتحديد تركيبها الكيميائي بوساطة طريقه كروماتوكرافيا الغاز-مطياف الكتلة gas chromatography-mass spectrometry
| Main Author: | Al – Khafaji, Sabreen Abdul Amir Kamal |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
University of Babylon
, 2018
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| Subjects: | |
| Online Access: |
https://www.journalofbabylon.com/index.php/JUBPAS/article/view/938 https://www.journalofbabylon.com/index.php/JUBPAS/article/view/938/706 |
Daftar Isi:
- تم تحليل النواتج الحيوية الثانوية لبكتريا Morganella morganii باستخدام تقنيات التحليل الطيفي الكتلي للغاز (GC-MS)، ثم تم تقييم نشاط هذه النواتج للبكتريا المستخلصة بكحول الميثانول ضد الفطريات مقارنة مع بعض المضادات الحياتية . كشف تحليل GC-MS لـ Morganella morganii عن وجود Tricyclo , 3-Methoxybenzaldehyde semicarbazone, undecan-1-amine, carboxaldehyde , 1-methyl-, oxime ,(Z)-(+), 4-(2,5-Dihydro-3-methoxyphenyl) butylamine, Paromomycin, 1, 5, 5-Trimethyl-6-methylene-cyclohexene, 9-Borabicyclo [3. 31], Benzenemethanol , nonane , 9-mercapto-2-(2-aminopropoxy)-3-methyl, Acetamide , N-(6-acetylaminobenzothiazol-2-yl)-2-(adamantan, rin-6-carboxylic acid , N-(2,5-Dicyano-3,4-dihydro-2H-pyrrol-2-yl)- acetamide , 3,10-Dioxatricyclo4-(2,5-Dihydro-3-methoxyphenyl)butylamine, [4.3.1.0(2,4)] phenylmethyl ester, 3,7-Diazabicyclo dec-7-ene, 3-Cyclohex-3-enyl-propionic acid, Eicosanoic acid [3.3.1] 9,9-dimethyl-, nonane ,Dithiocarbamate , dl-Homocysteine, 2-(2-Furyl)pyridine, S-methyl-,N-(2-methyl-3-oxobutyl)-, 1,7-Dioxa-10-thia-4,13-diazacyclopentadeca-5,9,12-trione, 5,7-Dodecadiyn-1,12-diol, 1-(β-d-Arabinofuranosyl)-4-O-difluoromethyluracil, Uric acid, Pyrrolo[1.2-a]pyrazine-1,4-dione, hexahydro-,12-Methyl-oxa-cyclododecan-2-one, Phthalic acid, butyl undecyl ester, 9,12,15-Octadecatrienoic acid, 2,3-bis (acetyloxy) propyl ester , methyl ester, 12- Dimethylamino-10-oxododecanoic acid, 1, 2, 4-Trioxolane-2-octanoic acid 5-octyl-, Octahydrochromen-2-one, L-Aspartic acid , N-glycyl- ,2H-Oxecin -2-one,3,4,7,8,91,10-hexahydro-4-hydroxy-10-meth, Thiazolo [4, 5- d] pyrimidine- 5, 7 (4H,6H)- dione, 3, 6,12-Trimethyl-1, 4, 7, 10,13,16-hexaaza-cyclooctadecane, 2-lodohiistidine, 2-amino-4- (2-ph, Dec-9-en-6-oxo-1-ylamide, 2, 5-Piperazinedione, 3, 6-bis (2-methylpropyl)-, 9-Octadecenamide, (Z)-, 3',8,8'-Trimethoxy-3-piperidyl-2,2'-binaphthalene-1,1',4,4'-tetra. كما استخدمت عدد من النباتات الطبية لمعرفة تأثيرها على نمو هذه البكتريا . كان مستخلص الحنظل Citrullus colocynthis (الخام) نشط للغاية (6.39 ± 0.27) ملم. وأظهرت نتائج النشاط المضاد للفطريات التي تنتجها Morganella morganii أن المركبات المتطايرة كانت فعالة للغاية لقمع نمو الفطر Aspergillus terreus (5.613 ± 0.23) . تنتج Morganella morganii العديد من نواتج الأيض الثانوية الهامة ذات الأنشطة البيولوجية العالية. من هذه البحث نتبين اهمية هذه البكتريا في انتاج العديد من المركبات الثانوية النشطة بايويوجيا في الصناعات ال
- The analysis of bioactive was done by used gas chromatography-mass spectroscopy(GC-MS) method then antifungal and antimicrobial activity for methanolic extract was measured in the lab. The analysis of Morganella morganii by GC-MS revealed the existence of the Tricyclo, 3-Methoxybenzaldehyde semicarbazone , undecan-1-amine, carboxaldehyde , 1-methyl-,oxime ,(Z)-(+), 4-(2,5-Dihydro-3-methoxyphenyl) butylamine , Paromomycin , 1,5,5-Trimethyl-6-methylene-cyclohexene, 9-Borabicyclo[3.31], Benzenemethanol , nonane , 9-mercapto-2-(2-aminopropoxy)-3-methyl, Acetamide , N-(6-acetylaminobenzothiazol-2-yl)-2-(adamantan, rin-6-carboxylic acid , N-(2,5-Dicyano-3,4-dihydro-2H-pyrrol-2-yl)- acetamide, 3,10-Dioxatricyclo4-(2,5-Dihydro-3-methoxyphenyl)butylamine, [4.3.1.0(2,4)] phenylmethyl ester, 3,7-Diazabicyclo dec-7-ene, 3-Cyclohex-3-enyl-propionic acid, Eicosanoic acid [3.3.1] 9,9-dimethyl-, nonane ,Dithiocarbamate , dl-Homocysteine, 2-(2-Furyl)pyridine, S-methyl-,N-(2-methyl-3-oxobutyl)-, 1,7-Dioxa-10-thia-4,13-diazacyclopentadeca-5,9,12-trione, 5,7-Dodecadiyn-1,12-diol, 1-(β-d-Arabinofuranosyl)-4-O-difluoromethyluracil, Uric acid, Pyrrolo[1.2-a]pyrazine-1,4-dione , hexahydro-,12-Methyl-oxa-cyclododecan-2-one, Phthalic acid , butyl undecyl ester, 9,12,15-Octadecatrienoic acid , 2,3-bis(acetyloxy)propyl ester, , methyl ester, 12-Dimethylamino-10-oxododecanoic acid , 1,2,4-Trioxolane-2-octanoic acid 5-octyl-, Octahydrochromen-2-one, L-Aspartic acid, N-glycyl-,2H-Oxecin-2-one , 3,4,7,8,91,10-hexahydro-4-hydroxy-10-meth, Thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione , 3,6,12-Trimethyl-1,4,7,10,13,16-hexaaza-cyclooctadecane, 2-lodohiistidine, 2-amino-4-(2-ph,Dec-9-en-6-oxo-1-ylamide,2,5-Piperazinedione,3,6-bis(2-ethylpropyl)-, 9-Octadecenamide , (Z)-, 3',8,8'-Trimethoxy-3-piperidyl-2,2'-binaphthalene-1,1',4,4'-tetra . Citrullus colocynthis (Crude) was very highly active (6.39±0.27) mm anti-fungal activity of Morganella morganii showed that unstable compounds ( volatile )were effective hight to decrease the growth of Aspergillus terreus (5.613±0.23). the production of Morganella morganii give many essential secondary metabolites with a lot of biological activities. in pharmacy we depend on the significance of using bioactive compounds to made drugs for many diseases as for treatment, compounds purification of which produced by Morganella morganii will be benefit for use.