Assessment of circulating PPAR-γ Level as a risk and diagnostic biomarker in Acute Coronary Syndrome
| Main Authors: | Ali, Sana Abdul-Jabbar, Al-Shalah, Hayder, Al-Salihi, Oday |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
University of Babylon
, 2018
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| Subjects: | |
| Online Access: |
https://www.journalofbabylon.com/index.php/JUBPAS/article/view/1508 https://www.journalofbabylon.com/index.php/JUBPAS/article/view/1508/1219 |
Daftar Isi:
- متلازمة الشريان التاجي الحاد: هو مصطلح يشمل كلا من الذبحة الصدرية غير المستقرة واحتشاء عضلة القلب. وهو اضطراب يهدد الحياة ويظل مصدراً لارتفاع معدلات المراضة والوفيات على الرغم من التقدم في العلاج.... تقييم المخاطر باستخدام عوامل الخطر وعلامات المخاطر, واحد من علامات الخطر الناشئة هو ارتفاع مستوى تعميم -يتم عامل النسخ محتمل الهامة PPAR-γ . تمثل هذه الدراسة محاولة لتقييم دور هذه التحليلات كمؤشر مرتبط بالمخاطر للأحداث القلبية الوعائية المستقبلية، وتقييم PPRA-Yكمؤشر تشخيصي جديد محتمل لـمتلازمة الشريان التاجي. تم اخذ 80 مريض وتم تشخيصهم بمتلازمة الشريان التاجي ودراسة عامل النسخ المذكور انفا عليهم وتبين وجود صلة ذات اهميه مع متلازمة الشريان التاجي.
- Acute coronary syndrome (ACS) is a term that encompasses both unstable angina and myocardial infarction (MI) with or without ST-segment elevation. “It is a life-threatening disorder that remains a source of high morbidity and mortality despite advances in treatment. “Risk assessment done by using risk factors and risk markers. “One of the emerged risk markers is high circulating level of PPAR-γ (a potentially important transcription factor). “This study represents a try to evaluate the role of this analyte as a risk biomarker for future cardiovascular events, and evaluation of PPAR-γ as a possible diagnostic biomarker for MI. “It was a case –control study enrolled 160 subjects; 80 patients diagnosed as ACS patients by expert physicians. “An equivalent age and sex matched population without coronary disease with similar risk factors considered a control group. Serum levels of PPAR-γ were measured by using ELISA technique, cTpI was investigated by qualitative membrane- based immunoassay. “Independent sample t-test was used to compare means between two groups. “ANOVA were used to compare means between different groups, p value ≤ 0.05 is significant. “There were significant differences in mean serum levels of PPAR-γ, by patients and control. “There was a significant difference in PPAR- γ serum levels between positive and negative cTpI groups. “There was an insignificant difference in PPAR- γ level among different ECG finding groups. “Circulating level of PPAR- γ seems to be used as a risk biomarker for ACS, it is suggested that it could be used as a diagnostic biomarker for MI.