Penambatan molekul senyawa turunan orizanol terhadap enzim 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reduktase
| Main Authors: | Aziz, Syaikhul, Adliani, Nur, Sukrasno, Sukrasno |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Lembaga Penelitian, Pengabdian Masyarakat, dan Penjaminan Mutu (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia
, 2020
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| Online Access: |
https://journal.itera.ac.id/index.php/jsat/article/view/191 https://journal.itera.ac.id/index.php/jsat/article/view/191/108 |
Daftar Isi:
- Oryzanol has been reported to reduce serum total cholesterol (hypolipidemic agent) by inhibiting HMG-CoA reductase, an enzyme responsible for the metabolic pathway that produces cholesterol and isoprenoid. The purpose of this experiment is to determine the inhibition activity of oryzanol derivatives on HMG-CoA reductase by molecular docking. Four structure of oryzanol derivatives, Lanosteryl-ferulate, Brassicasteryl-ferulate, Lupeol-ferulate, and Cholesteryl-ferulate were used as ligands for molecular docking. The HMG-CoA reductase structure was obtained from protein data bank and the study was performed using AutoDock Tools as a molecular docking software. All oryzanol derivatives show binding affinity against HMG-CoA reductase. Lupeol-ferulate was predicted to be the best inhibitory activity against HMG-CoA reductase because of molecular docking.