Synthesis of Mn(II) Complexes-Carboxymethyl Chitosan Schiff Base Salicylaldehyde and Antibacterial Activity
| Main Authors: | Ismiyarto, Ismiyarto, Saputri, Niken Windi, Rahmatia, Liswinda Zafirah, Sarjono, Purbowatiningrum Ria, Ngadiwiyana, Ngadiwiyana, Prasetya, Nor Basid Adiwibawa, Bima, Damar Nurwahyu |
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| Other Authors: | Faculty of Science and Mathematics, Diponegoro University |
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Syarif Hidayatullah State Islamic University
, 2021
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| Subjects: | |
| Online Access: |
http://journal.uinjkt.ac.id/index.php/valensi/article/view/19866 http://journal.uinjkt.ac.id/index.php/valensi/article/view/19866/pdf_1 http://journal.uinjkt.ac.id/index.php/valensi/article/downloadSuppFile/19866/4143 |
Daftar Isi:
- The development of compounds with a better antibacterial activity is highly needed. One way to achieve this is by modifying the structure of the compound using chitosan as a starting material, because of its abundant natural source in Indonesia, its biodegradable properties, and its structure where free amines are present. This study aims to obtain Mn(II) -Carboxymethyl Chitosan Schiff Base-Salicylaldehyde complex to increase its antibacterial activity against Staphylococcus aureus (Gram positive) and Escherichia coli (Gram negative). Schiff Base carboxymethyl chitosan-salicylaldehyde was synthesized from carboxymethyl chitosan with salicylaldehyde. Next, the Schiff Base Carboxymethyl Chitosan-Salicylaldehyde was complexed with MnCl2.4H2O and then characterized by FTIR, UV-Vis Spectrophotometer, and AAS and tested for antibacterial activity with the disc diffusion method against Staphylococcus aureus and Escherichia coli. The product of Carboxymethyl Chitosan Schiff Base-salicylaldehyde is a brownish yellow solid with a yield of 64% (w/w) and has antibacterial activity against Staphylococcus aureus (clear zone diameter 11 mm) and Escherichia coli (clear zone diameter 13 mm). The product of Mn(II) Complexes-Carboxymethyl Chitosan Schiff Base-salicylaldehyde is a black solid with a yield of 59% (w/w) and has antibacterial activity against Staphylococcus aureus (clear zone diameter 13 mm) and Escherichia coli (clear zone diameter 17 mm).