Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines
| Main Authors: | Mayanti, Tri, Amir, Nur Insani, Katja, Dewa Gede, Fajriah, Sofa, Darmawan, Ahmad, Supratman, Unang, Awang, Khlaijah, Shiono, Yoshihito |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Syarif Hidayatullah State Islamic University
, 2020
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| Subjects: | |
| Online Access: |
http://journal.uinjkt.ac.id/index.php/valensi/article/view/15976 http://journal.uinjkt.ac.id/index.php/valensi/article/view/15976/pdf |
Daftar Isi:
- Three steroids, 3α-hydroxystigmast-5(6), 22-diene-7-one (1), stigmasterol (2) and 3-hydroxy-7β-methoxystigmast-5(6)-ene (3), were isolated from the stem bark of Dysoxylum nutans. The chemical structures were identified by spectroscopic data, which includes IR, 1D-NMR, 2D-NMR, and HR-TOFMS as well as by comparing previously reported spectral data. Compounds 1-3 were tested for cytotoxic effect against MCF-7 breast cancer cell lines and compound 1 showed the strongest cytotoxic activity with an IC50 value of 20.13 ± 0.06 μM.