Preparation and Characterization of Mefenamic Acid Microcapsule using Sodium Alginate Polymer by Ionic Gelation Methods
| Main Authors: | Mardikasari, Sandra Aulia, Suryani, Suryani, Puspitasari, Marwah |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Fakultas Farmasi Universitas Pancasila
, 2020
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| Online Access: |
http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/797 http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/797/542 |
Daftar Isi:
- Mefenamic acid belongs to a class of the non-steroidal anti-infl ammatory drugs that work asan analgesic. Mefenamic acid is sensitive to the light and temperature, also has unpleasant odors andtastes. Microencapsulation technology is a technique where the active substance is coated by a thin layerso that the active substance is protected from environmental infl uences. The aim of this research was toformulate and characterize mefenamic acid in the form of microcapsule using ionic gelation methodswith sodium alginate. Preparation was done by comparing the concentrations of sodium alginatepolymers namely, 1%, 2%, and 3%. Success parameters include the entrapment effi ciency, particleshape, particle size distribution, and dissolution. The results on the entrapment effi ciency using UVVISspectrophotometer showed a concentration of 1% polymer has a high value of 94.02%, for particleshapes using the optical microscope showed that three formulas were spherical with the smallest particlesize distribution was 1266 μm. The dissolution test by type II dissolution test showed that the higherthe concentration of polymer used, the slower the drug release. This research provides an alternativeformulation of mefenamic acid microcapsule by using sodium alginate polymer.
- Asam mefenamat termasuk dalam golongan obat anti infl amasi non-steroid yang bekerjasebagai analgetik. Asam mefenamat rentan terhadap pengaruh cahaya serta suhu dan memiliki baudan rasa yang kurang enak. Teknologi mikroenkapsulasi merupakan teknik dimana zat aktif dilapisioleh lapisan tipis sehingga zat aktif terlindung dari pengaruh lingkungan. Tujuan dari penelitian iniuntuk memformulasi dan mengkarakterisasi asam mefenamat dalam bentuk mikrokapsul menggunakanmetode gelasi ionik dengan polimer natrium alginat. Preparasi dilakukan dengan membandingkankonsentrasi polimer natrium alginat yakni, 1%, 2%, dan 3%. Parameter keberhasilan meliputi efi siensipenjerapan, bentuk partikel, distribusi ukuran partikel, dan disolusi. Hasil pada efi siensi penjerapanmenggunakan alat spektofotometer UV-VIS menunjukkan konsentrasi polimer 1% memiliki nilaiefi siensi penjerapan yang tinggi yakni sebesar 94,02%, pengamatan bentuk partikel menggunakanmikroskop optik menunjukkan bahwa ketiga formula berbentuk sferis dengan distribusi ukuran partikelterkecil yakni 1266 μm. Uji disolusi menggunakan alat disolusi tipe II menunjukkan bahwa semakintinggi konsentrasi polimer yang digunakan maka pelepasan obat akan semakin lambat. Penelitian inimemberikan alternatif formulasi mikrokapsul asam mefenamat menggunakan polimer natrium alginat.