Physical Stability of Curcumin Transethosome Using Combinations Tween 60 and Span 60 as Surfaktan
| Main Authors: | Srifiana, Yudi, Amalia, Anisa, Yusnia, Yusnia |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Fakultas Farmasi Universitas Pancasila
, 2020
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| Online Access: |
http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/796 http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/796/541 |
Daftar Isi:
- Curcumin has low solubility in water and has low stability so that a drug delivery system is needed that can overcome these problems. One delivery system that can be used to overcome these problems is transethosome. Transethosome is composed of several component, one of them is surfactant. Surfactant is a component that can help improve the stability of the transethosome system so that in this study research was conducted on the eff ect of the use of a combination of surfactants (tween 60 and span 60) on the physical stability of transethosome curcumin. In this study used a combination of tween 60 and span 60 with a ratio of 1: 2, 1: 1, 2: 1 at a concentration of 5%. Transethosome formed then characterized include organoleptic, viscosity, particle size and particle size distribution, zeta potential, adsorption effi ciency and pH. Transethosome characteristics were observed for 8 weeks to see the physical stability of the transethosome. The results at week 0 indicate that the transethosome formed a suspension with orange color and smelled of phosphatidylcholine with the highest viscosity in formula 3, has a particle size of 1-1000 nm, polydispersity 0-0.571, has a negative zeta potential value, has an absorption effi ciency above 80 % and pH 8.5-10.0. Physical stability test results show the use of a combination of tween 60 and span 60 with rasio 3:1 (F3) can improve the physical stability of transethosome curcumin.
- Kurkumin memiliki kelarutan yang rendah di dalam air serta memiliki stabilitas yang rendah sehingga diperlukan suatu sistem penghantaran obat yang dapat mengatasi permasalahan tersebut, salah satunya adalah transethosome. Transethosome tersusun dari beberapa komponen salah satunya surfaktan. Surfaktan merupakan komponen yang dapat membantu meningkatkan stabilitas sistem transethosome sehingga pada penelitian ini dilakukan penelitian mengenai pengaruh penggunaan kombinasi surfaktan (tween 60 dan span 60) terhadap stabilitas fi sik transethosome kurkumin. Pada penelitian ini digunakan kombinasi tween 60 dan span 60 dengan perbandingan 1:2, 1:1, 2:1 pada konsentrasi 5%. Transethosome yang terbentuk kemudian dikarakterisasi meliputi organoleptis, viskositas, ukuran partikel dan distribusi ukuran partikel, potensial zeta, efi siensi penjerapan dan pH. Pengamatan karakteristik transethosome dilakukan selama 8 minggu untuk melihat stabilitas fiisik dari transethosome. Hasil pada minggu ke 0 menunjukkan bahwa transethosome yang terbentuk suspensi dengan warna orange dan berbau khas fosfatidilkolin, dengan viskositas tertinggi pada formula 3, memiliki ukuran partikel 1-1000 nm, polidispersitas 0-0,571, memiliki nilai potensial zeta negatif, memiliki efi siensi penjerapan diatas 80% dan pH 8,5-10,0. Hasil uji stabilitas fisik menunjukkan penggunaan kombinasi tween 60 dan span 60 dengan perbandingan 3:1 (F3) dapat meningkatkan stabilitas fi sik transethosome kurkumin