Anti–Platelet Aggregation and Anti-Inflamatory Eff ect from Ethanol Extract Of Tembelekan Leaves (Lantana Camara Linn.) In Vivo
| Main Authors: | Dwi Sandhiutami, Ni Made, Desmiaty, Yesi, Darmastuti, Nattika Sari, Muhammad, Fahri |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Fakultas Farmasi Universitas Pancasila
, 2020
|
| Online Access: |
http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/707 http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/707/536 |
Daftar Isi:
- Atherosclerosis is chronic inflammatory disease that can be prevented with anti-inflammatoryactivity agents and reduce thrombus formation in blood vessels. Tembelekan leaves (Lantana camaraLinn.) contain fl avonoids, saponins, and essential oils which potential to inhibit platelet aggregation andbe anti-inflammatory. This study aimed to test the in vivo anti-platelet aggregation and anti-inflammatoryactivity of tembelekan leaves. Platelet anti-aggregation test was carried out on mice by assessing thedecrease in plasma absorbance after addition of ADP. Mice were divided into normal group, positivecontrol group which was given clopidogrel and 3 test groups which were given Tembelekan leaf extractat a dose of 2.5, 5, 10 g/kgBW. In vivo anti-inflammatory test used the Winter method with intraplantar1% carrageenan as inducer. There was a signifi cant decrease in plasma absorbance after addition ofADP at doses of 2.5 and 5 g/kgBW of tembelekan leaves i.e 5.47% and 12.28% compared to thenormal group. Positive control and dose of 10 g/kgBW gave the same eff ect. In anti-inflammatorytest, the doses of 3.2 and 6.4 g/kgBW of tembelekan leaves gave percentage value of inhibition whichwas not signifi cantly diff erent with diclofenac sodium. Tembelekan leaves potentially as anti-plateletaggregation and anti-inflammatory properties.
- Aterosklerosis merupakan penyakit inflamasi kronis yang dapat dicegah dengan bahan yangmemiliki aktivitas anti-inflamasi serta mengurangi pembentukan trombus di pembuluh darah. Dauntembelekan (Lantana camara Linn.) mengandung fl avonoid, saponin, dan minyak atsiri yang memilikipotensi penghambatan agregasi platelet dan anti-infl amasi. Penelitian ini bertujuan menguji aktivitasanti-agregasi platelet dan anti-inflamasi daun tembelekan secara in vivo. Uji anti-agregasi plateletdilakukan pada mencit dengan menilai penurunan serapan plasma setelah penambahan ADP. Mencitdibagi dalam kelompok normal, kontrol positif yang diberi clopidogrel dan 3 kelompok uji yang diberiekstrak daun tembelekan dosis 2,5; 5; 10 g/kg. Uji anti-infl amasi secara in vivo pada tikus menggunakanmetode Winter dengan karagenan 1% intraplantar sebagai penginduksi. Terjadi penurunan serapanplasma setelah penambahan ADP yang signifi kan pada pemberian daun tembelekan dengan dosis 2,5dan 5 g/kg BB yaitu sebesar 5,47% dan 12,28% dibandingkan dengan kelompok normal. Kontrol positifdan dosis 10 g/kg BB memberikan efek setara. Pada uji anti-infl amasi, dosis 3,2 dan 6,4 g/kgBB dauntembelekan memberikan nilai persentase penghambatan yang tidak berbeda bermakna dengan natriumdiklofenak terhadap udema tapak kaki tikus. Daun tembelekan berpotensi sebagai anti-agregasi plateletdan anti-inflamasi.