Anti–Platelet Aggregation Eff ect from Ethanol Extract of Salam Leaves (Syzygium polyanthum (Wight) Walp.) on Mice
| Main Authors: | DEWI, RIKA SARI, SANDHIUTAM, NI MADE DWI, RAHARJO, SULISTYO |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Fakultas Farmasi Universitas Indonesia
, 2017
|
| Online Access: |
http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/449 http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/449/298 |
Daftar Isi:
- Salam leaves (Syzygium polyanthum (Wight) Walp.) contains fl avonoids, volatile oil and phenolic acid that can inhibiting platelet aggregation induced by ADP (adenosine diphospate), arachidonic acid, epinephrine, thrombin, collagen and aff ecting the activity enzyme ectonucleotidase so it can be used as anti-platelet drug. The purpose of this study was to investigated 70% ethanol extract of salam leaves have anti-platelet aggregation eff ect and increase of dose can also increase anti-platelet aggregation. This study was performed in 5 groups, each group consisted of 5 mice there were: groups of positive control, normal control, 70% ethanol extract leaves doses (150, 300, 450) mg/ kg, each group is given orally once daily during 8 days and measurements of parameters at day-0 and day-9th. The results of this study was 70% ethanol extract of leaves of salam leaves doses (150,300, 450) mg/kgBW showed the eff ects prolong bleeding time, coagulation time, enhance the decreased plasma absorbance after the addition of ADP. From the measurement parameter bleeding time, coagulation time and measurement decreased plasma absorbance after the addition of ADP that 70% ethanol extract of salam leaves doses 150, 300 and 450 mg/kgBW have anti-platelet aggregation eff ect and increase of dose was able to increase the eff ect anti-platelet aggregation.
- Daun salam (Syzygium polyanthum (Wight) Walp.) memiliki kandungan fl avonoid, minyak atsiri dan asam fenolat yang berkhasiat menghambat agregasi platelet yang diinduksi ADP(Adenosin difosfat), asam arakidonat, epinefrin, trombin, kolagen dan mempengaruhi aktivitas enzim ektonukleotidase sehingga dapat digunakan sebagai obat anti-platelet. Tujuan dari penelitian ini untuk mengetahui bahwa ekstrak etanol 70% daun salam memiliki efek anti-agregasi platelet serta peningkatan dosisnya memiliki kemampuan meningkatkan efek anti-agregasi platelet. Penelitian ini dilakukan pada 5 kelompok mencit yang terdiri dari masing-masing 5 mencit, yaitu: kelompok kontrol positif, kontrolnormal, ekstrak etanol 70% daun salam dosis (150, 300, 450) mg/kg BB, masing–masing kelompok diberikan secara per oral satu kali sehari selama 8 hari dan dilakukan pengukuran parameter pada hari ke-0 dan hari ke-9. Hasil uji efek anti-agregasi platelet menunjukkan bahwa ekstrak etanol 70% daun salam dosis (150, 300, 450) mg/kg BB menunjukkan efek memperpanjang waktu pendarahan, waktu koagulasi serta memperbesar penurunan serapan plasma setelah penambahan ADP. Dari hasil pengukuran parameter waktu pendarahan, waktu koagulasi dan penurunan serapan plasma setelah penambahan ADP bahwa ekstrak etanol dosis 150, 300 dan 450 mg/kg BB daun salam memiliki efek anti-agregasi platelet dan peningkatan dari dosis dapat meningkatkan efek anti-agregasi platelet.