Penetapan Simultan Kadar Fenilpropanolamin Hidroklorida dan Klorfeniramin Maleat dalam Tablet secara Spektrofotometri
| Main Authors: | FARIDAH, FARIDAH, YANTIH, NOVI, HERAWATI, NETTY |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Fakultas Farmasi Universitas Indonesia
, 2008
|
| Online Access: |
http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/417 http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/417/291 |
Daftar Isi:
- Simultaneous determination of phenylpropanolamine hydrochloride and chlorpheniramine maleate in tablets by spectrophotometry was carried out. The method is based upon total absorption of the two compounds in a mixture which can be applied to quantify each ofthe component. The absorption of phenylpropanolamine hydrochloride and chlorpheniramine maleate in 0.1 N hydrochloric acid were measured at the maximum Wavelength of phenylpropanolamine hydrochloride (256.7 nm) and that of chlorpheniramine maleate (262.6 nm), with a correlation coefficient of 0.999. A high precision could be obtained as shown by the CV of 0.2139-0.4962% for phenylpropanolamine hydrochloride and 0.3182- 0.5289% for chlorpheniramine maleate, While the recoveries ofphenylpropanolamine hydrochloride and chlorpheniramine maleate were 99.93% ± 0.43% and 99.76% ± 0.39%, respectively. The proposed method is simple, with a high accuracy and suitable for the simultaneous determination ofphenylpropanolamine hydrochloride and chlorpheniramine maleate in tablets, Without prior separation.