Isolasi Senyawa Aktif dari Ekstrak Hipokotil Sarang Semut (Myrmecodia pendens Merr. & Perry) sebagai Penghambat Xantinoksidase
| Main Authors: | SIMANJUNTAK, PARTOMUAN, FANNY, FANNY, SUBROTO, MUHAMMAD AHKAM |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Fakultas Farmasi Universitas Indonesia
, 2010
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| Online Access: |
http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/366 http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/366/254 |
Daftar Isi:
- Medicinal plant called “sarang semut”, Myrmecodia pendens Merr. & Perry (Rubiaceae), is an epiphyt plant traditionally used in Papua for healing various diseases such as hyperuricemia, rheumatic, and cancer. A chemical compound recognized as xanthinoxidase inhibitor has been isolated from n-buthanol fraction of the plant extract. The isolation was carried out by column chromatography (SiO2, CHCI3-MeOH = 5:1-1:1) and the purification Was conducted using high pressure liquid chromatography (RP, C-18; MeOH-water = 5 : 1). The activity test for Xanthinoxidase inhibitor Was performmed by using modilied Noro method. The pure compound showed xanthinoxidase inhibitor activity of IC50 at 79,77%.