Formulation of Mucoadhesive Tablets of Ethanolic Extract Mango’s Leaves Variety Bapang (Mangifera indica L. ‘Bapang’) as Antidiabetic Using Guar Gum Matrix
| Main Authors: | FITHRIYANI, LIA NADIA, K, DHADHANG WAHYU, R, EKA PRASASTI NUR |
|---|---|
| Format: | Article info eJournal |
| Terbitan: |
Fakultas Farmasi Universitas Indonesia
, 2014
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| Online Access: |
http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/144 |
Daftar Isi:
- Ethanolic extract of mango’s leaves variety of bapang (Mangifera indica L. ‘Bapang’) has been known to contains mangiferin which has antidiabetic activity in patients with diabetes mellitus. This study aimed to obtain a formulation of tablets of ethanolic extract mango leaves with variety of bapang with good physical characteristic and know the effect of variations concentration of guar gum on the properties of mucoadhesive. Tablets were prepared using wet granulation method varying levels of guar gum as a bioadhesive matrix. Tablets were tested physical characteristics and mucoadhesive strength in vitro by using a rotating cylinder and observed within 8 hours. The results showed that the tablets of ethanolic extract mango leaves with variety of bapang have good physical characteristics. The result of mucoadhesive in vitro test showed that all formulas have good mucoadhesive strength. Mucoadhesive strength increased with the increase in the concentration of guar gum. The result of this research showed that the tablets of formula 4 with the highest concentration of guar gum showed the best mucoadhesive strength where they could be attach of 7 ± 1 hour.
- Ekstrak etanol daun mangga bapang (Mangifera indica L. ‘Bapang’) diketahui mengandung mangiferin yang mempunyai aktivitas antidiabetes pada pasien diabetes melitus. Penelitian ini bertujuan untuk ndaatkan ua tat ktak tan daun ana aan an nui aat iat ik tablet dan mengetahui pengaruh variasi penambahan matriks guar gum terhadap sifat mukoadesif tablet. Tablet dibuat menggunakan metode granulasi basah yang memvariasikan kadar guar gum sebagai atik iadi at diui iat ikna dan daa ukadina diui caa in vitro menggunakan alat silinder berputar dan diamati selama 8 jam. Hasil penelitian menunjukkan bahwa tablet ekstrak tan daun ana aan unai kaaktitik ik an nui aat iat ik tat i mukoadesif secara in vitro menunjukkan bahwa semua formula tablet memiliki daya mukoadesif yang bagus. Daya mukoadesif meningkat seiring meningkatnya guar gum. Hasil penelitian menunjukkan formula 4 dengan kadar guar gum paling tinggi memiliki daya mukoadesif yang paling besar yaitu dapat melekat selama 7±1 jam.