The isolation and identification of antimalarial agents of the n-hexane fraction of the neem leaves (Azadirachta indica A. Juss)
| Main Authors: | Suryawati, ., Yusuf, Hanifah, Sofia, . |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Syiah Kuala University
, 2011
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| Online Access: |
http://www.jurnal.unsyiah.ac.id/AICS-SciEng/article/view/1937 http://www.jurnal.unsyiah.ac.id/AICS-SciEng/article/view/1937/1875 |
Daftar Isi:
- Abstract. Following the study which confirmed the antimalarial activity of the n-hexane fraction of the neem leaves (Azadirachta indica A.Juss), a research that aimed to reveal the active compounds act as antimalarial agents had been conducted. In this study, the n-hexane fraction of neem leaves were analyzed using the phytochemical, spectroscopic and chromatographic methods. The chemical compounds, suspected to have an antimalarial activity, were isolated using the thin-layer chromatographic method with several solvents which different in their polarity. The visualizing reagents were used to characterize the compounds. The result showed that the n-hexane fraction of neem leaves contained of steroids, terpenoids and fenols. Analysis by gas chromatography-mass spectroscopy showed that fenol derivatives existed in the largest amount. The compounds were identified as benzyl benzoat (25.63%), tetracosane (17.51%) and hexadecanal (14.61%)