Formulasi dan Evaluasi Tablet Dispersi Padat Kalsium Atorvastatin
| Main Authors: | Gozali, Dolih, Wardhana, Yoga Windhu, Shofa, Shofa |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Program Studi Farmasi FMIPA Universitas Lambung Mangkurat
, 2019
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| Subjects: | |
| Online Access: |
https://ppjp.ulm.ac.id/journal/index.php/pharmascience/article/view/5824 https://ppjp.ulm.ac.id/journal/index.php/pharmascience/article/view/5824/4880 |
Daftar Isi:
- ABSTRAK Kalsium Atorvastatin merupakan obat antihiperlipidemia golongan statin. Berdasarkan Biopharmaceutical Classification System (BCS), Kalsium Atorvastatin termasuk dalam golongan obat yang memiliki kelarutan rendah. Kelarutan atorvastatin yang rendah dalam air menyebabkan laju disolusi rendah. Salah satu cara untuk meningkatkan disoluisi adalah dengan dispersi padat. Dispersi padat yaitu suatu keadaan dimana satu atau lebih bahan aktif terdispersi dalam polimer pembawa pada keadaan padat. Pada penelitian sebelumnya (Lakshmi, 2010), dispersi padat atorvastatain kalsium dengan PEG 6000 (1:3) menunjukkan hasil laju disolusi yang tertinggi. Pada penelitian ini dispersi padat kalsium atorvastatain (ATC) dengan PEG 6000 sebagai pembawa hidrofilik dalam perbandingan 1:3, 1:6, 1:9 Kemudian hasilnya dibuat tablet dengan metode kempa langsung. Uji disolusi dilakukan dengan Spektrofotometri UV-Vis. Hasil disolusi yang dilakukan, menunjukkan bahwa bahwa adanya peningkatan laju disolusi dilihat dari persen terdisolusi yang dihasilkan setelah 30 menit yaitu sebesar formula 1 (ATC tanpa PEG 6000) 25,63%, formula 2 (1:3) 27,90 %), formula 3 (1:6) 31,83 % dan formula 4 (1:9) 13,61 %. Kata Kunci : Kalsium Atorvastatin, Dispersi Padat, Disolusi, PEG 6000 ABSTRACTAtorvastatin calcium is anti-hyperlipidemia drugs known as statins. Based on Biopharmaceutical Classification System (BCS), Calcium Atorvastatin belongs to a class of drugs which have low solubility. The low solubility of atorvastatin in water causes low dissolution rate. One way to improve disolution is by solid dispersion. Solid dispersion is a condition which one or more active ingredients dispersed in a polymer carrier in the solid state. In the previous study (Lakshmi, 2010), solid dispersion of calcium atorvastatain with PEG 6000 (1: 3) showed the results of highest dissolution rate. In this study, solid dispersions of calcium atorvastatain (ATC) with a hydrophilic PEG 6000 as a carrier in a ratio of 1: 3, 1: 6, 1: 9 Then the results are made into tablet by direct compress method. Dissolution rates are tested by UV-Vis spectrophotometry. The dissolution result shows that there is an increase of the dissolution rate, viewed by percent dissolved after 30 minutes in the amount of formula 1 (ATC without PEG 6000) 25.63%, formula 2 (1: 3) 27.90%), formula 3 (1: 6) 31.83% and the formula 4 (1: 9) 13.61%.Keyword : Atorvastatin calcium, Solid Dispersion, Dissolution, PEG 6000