Effectiveness Curcuma Longa to Prevent Cells Damage in Early Pregnant Mice with Acute Toxoplasmosis
| Main Authors: | Simanjuntak, Tigor Peniel, Hatta, Mochammad, Rauf, Syahrul, Tahir, Andi Mardiah, Yusuf, Irawan, Taslim, Nurpuji Astuti, Sirait, Robert Hotman, Prabandari, Silvia Arin |
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| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Department of Obstetrics and Gynecology, Faculty of Medicine of Padjadjaran University
, 2019
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| Subjects: | |
| Online Access: |
http://repository.uki.ac.id/2610/1/Effectivenesscurcumalonga.pdf http://repository.uki.ac.id/2610/2/ReviewerEffectivenessCurcumaLonga.pdf http://repository.uki.ac.id/2610/ https://www.obgynia.com/obgyn/index.php/obgynia |
Daftar Isi:
- Objective: To prove the effectiveness of Curcuma longa to prevent damage cells by analyzing FOXP3 gene expression, TNF-α level, and histopathology of placental tissue. Methods: This study was conducted in 20 early pregnant mice, divided in 5 groups (K1-K5). K1-K4 were injected with tachyzoites. K1 and K2 were intervened with Curcuma longa 125 and 500 mg/kg/day. K3 were intervened with spiramycin 60 mg/kg/day, K4 were intervened with 0,2 distilled water, and K5 was not injected and intervened. IgG-IgM levels, FOXP3 mRNA expression, TNF-α level was examined serially, and placental mice were taken for histopathology examination 7 days after intervention. Results: FOXP3 mRNA expression in K1 and K2 increased significantly 7 days after intervention compared to K4 (p < 0.05), however the increased of expression in two groups has no significant difference. TNF-α level in K1 and K2 decreased significantly 7 days after intervention compared to K4 (p < 0.05), however the decrease of level in two groups has no significant difference. Hemorrhagic and necrotic cells were not found in K1 and K2, but were found in K3 (75%) and K4 (100%). Conclusion: Curcuma longa 125 mg is effective to prevent cells damage in early pregnant mice with acute toxoplasmosis.