Daftar Isi:
  • Silicone injection has been used since 40 years ago and at that time, many problems occurred such as migration, inflammation, and granuloma. In 1992, FDA prohibited silicone injection for cosmetic use.1 In addition to injection silicone may be introduced into our body or skin through food intake and cosmetic. Silicone has been widely used in daily cosmetics. Nowadays, due to technology advances, topical drugs can pass through skin barrier and can be penetrated into the skin, which has become a great concern as it may induce granuloma formation. There are relatively very few studies have been done on silicone concentration in normal skin.