Invitro Susceptibility Test of Candida spp. Isolates From Pulmonary Tuberculosis Suspected Patients to Antifungal Agents in Jakarta
| Main Authors: | Kumala, Widyasari, H. W, Mardiastuti |
|---|---|
| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
International Research Journals
, 2012
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| Subjects: | |
| Online Access: |
http://libprint.trisakti.ac.id/117/1/2012-Kumala.pdf http://libprint.trisakti.ac.id/117/ http://www.interesjournals.org/jmms/march-2012-vol-3-issue-3/invitro-susceptibility-test-of-candida-spp-isolates-from-pulmonary-tuberculosis-suspected-patientsto-antifungal-agents-in-jakarta |
Daftar Isi:
- Pulmonary infection is still a major health concern in Indonesia, and fungal infection is emerging. This may be related to widely used broad spectrum antibiotics, steroids, oral contraceptive, cytostatic, and chronic diseases.The aim of this study was to describe Candidaspp sensitivity pattern to various antifungal agents from pulmonary tuberculosis suspected patients. In this study, we used 176 sputum samples from tuberculosis suspected patients. The samples were cultured 3 times in Sabouraud dextrose agar. Yeast was identified by API 20 C AUX, while antifungal susceptibility test used ATB FUNGUS 3. There were 85 samples infected by yeast. As many as 74 isolates were identified as C. albicans (87.1%), 9 isolates were C. tropicalis (10.6%) and 2 were C. dubliniensis (2.4%). The susceptibility test showed six isolates of C. albicans and one isolate of C. tropicalis were intermediate against itraconazole. Only three isolates of C. albicans were resistant against itrazonazole, fluconazole, and voriconazole. Fortunately, they were still sensitive to amphotericine B and flucytosine. Almost half of tuberculosis suspected patients were infected by Candida spp. Most of them were still sensitive to various antifungal agents, although few C. albicans isolates were resistant against fluconazole, itraconazole, voriconazole.