A Rare Case: Amegakaryocyte Trombocytopenia As Early Manifestation Of Juvenile Systemic Lupus Erythematosus
| Main Authors: | Amalia, Yeni, Barlianto Susanto Nugroho, Wisnu |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Publikasi oleh Fakultas Kedokteran Universitas Islam Malang
, 2020
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| Subjects: | |
| Online Access: |
http://riset.unisma.ac.id/index.php/jki/article/view/8886 http://riset.unisma.ac.id/index.php/jki/article/view/8886/pdf |
Daftar Isi:
- ABSTRACTBACKGROUND Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which results in inflammation and eventual damage in a broad range of organ systems. Trombocytopenia is a common complication in patients with SLE, but amegakaryocyte trombocytopenia (AMT) is a rare disorder in SLE that characterized by isolated thrombocytopenia as a consequence of a marked decrease in or total absence of megakaryocytes in an otherwise normal bone marrow.CASE Lu, a wellnourished 13 y.o girl, complaining for high fever for 2 weeks, diminished body weight, artralgia, furunculosis, oral apthae and palour for 1 year, and bruising extremities for 2 motnhs. There was hepatosplenomegali. Laboratory findings: Hb 8.8 gr/dL, hct 27%, leucocytes 1.000/μL (ANC 230/μL), trombocytes 25,000/μL. Bone marrow puncture revealed amegacaryocyte thrombocytopenia, absence of megacaryocyte while erythropoesis and granulopoesis were normal. Anti ds DNA 223.8 iu/ml (+); ANA test 101.7 unit (+), microalbumin urine 10 mcg/mg (-), C3 complement 40 mg/dL ( ̄), ACA IgM 20.6 U/ml (+), ACA IgG 17.3 U/mL (+). The case fulfilled 5 criteria of ACR for SLE. The patient administered ceftazidim and gentamycin for febrile neutropenia, and high dose methylprednisolon injection for SLE.