Preclinical Study: Hepatoprotective Effects of ???Paliasa Tea Bag??? on Paracetamol-Induced LiverDamage in Rats
| Main Author: | Tayeb, Rosany |
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| Terbitan: |
, 2014
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| Subjects: | |
| Online Access: |
http://repository.unhas.ac.id/handle/123456789/8521 |
Daftar Isi:
- Paliasa leaves (Kleinhovia hospita L., Sterculiaceae) use in traditional South Sulawesi medicine for jaundice orhepatitis. Currently, Faculty of Pharmacy has made cooperation UNHAS and TPM for Industrial Scale Production efforts of???Paliasa Capsule??? that need preclinical studies. Methods: 45 rats were divided into four groups of 15 animals of each, having freeaccess to food and water ad libitum. Group I (control) was given Na-CMC, Group II were received paracetamol 1 g/kgBB and???Paliasa Tea Bag??? 179 mg/kgBB one a day, and Group III (negative control) was received paracetamol 1 g/kgBB only. Theactivities of of aspartate transaminase (AST) and alanine transaminase (ALT) were determined in serum (IFCC method).Superoxide dismutase (SOD), nitric oxide (NO) and glutathione peroxidase (GSH-Px) activity were measured in liverhomogenates (ELISA method). Result: ???Paliasa Tea Bag??? as hepatogenerative by decreased levels of AST (28.46%) and ALT(22.22%) and NO (8.0%) compared with negative control on paracetamol-induced hepatotoxicity in rat 1g/kgBW but didn???t beenable to increased GSH-Px and SOD activity. The effective dose of ???Paliasa Tea Bag??? is one a day for 4 weeks. Conclution:???Paliasa Tea Bag: suggest as a candidate of hepatogenerative drug