Effect of Consumption of Collagen Extract from Broiler???s Bone on Histological Kidney of Mice (Mus musculus) in South Sulawesi, Indonesia
| Main Authors: | Said, Muhammad Irfan, Abustam, Effendi, Nur Yuliati, Farida, Utomo, Budi |
|---|---|
| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2015
|
| Subjects: | |
| Online Access: |
http://repository.unhas.ac.id/handle/123456789/15536 |
Daftar Isi:
- Collagen, a hydrocolloid product resulted from partial hydrolysis of animal tissue, is currently used widely in food and pharmaceutical fields. Collagen extracts widely used by humans as a food supplement, especially for the elderly. Extract collagen from raw materials of broiler???s bone was chosen because it is relatively inexpensive and easy to obtain. The aims of this research was to study the effect of the consumption of collagen extract from broiler???s bone at different dose levels of the histological kidney of mice (Mus musculus). A total of 30 mice male, Balb/C strain, 2-3 months age, body weight of 20 to 25 grams was used as research. The objects were randomly divided into five groups and was used as research materials and each group consisted six of mice. Level dose of group A as control (0 mg/kg of body weight (bw), dose of group B (5 mg/kg of bw), dose of group C (50 mg/kg of bw), dose of group D (500 mg/kg of bw) and dose of group E (5000 mg/kg of bw). Microscopic observation in the kidney of mice was done after the consumption of collagen extracts. The results of this research showed that the dose limits extract collagen that is still acceptable of mice (Mus musculus) is 500 mg/kg of bw.