Kadar Glukosa dan Kolesterol Total Darah Tikus Putih (Rattus norvegicus L.) Hiperglikemik setelah Pemberian Ekstrak Metanol Akar Meniran (Phyllanthus niruri L.)
| Main Authors: | FAHRI, CHASBI, SUTARNO, , LISTYAWATI, SHANTI |
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| Format: | Article PeerReviewed application/pdf |
| Terbitan: |
, 2005
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| Subjects: | |
| Online Access: |
http://eprints.uns.ac.id/849/1/196906081997022001bio_farmasi_1.pdf http://eprints.uns.ac.id/849/ |
Daftar Isi:
- The aims of this research were to study the effect of methanol meniran (Phyllanthus niruri L.) root extract given to the blood glucose and total cholesterol content, and which level of concentration giving significant effect alloxan treatment. Meniran root contain ellagic acid as antioxidant which provide hypoglicemic capability to reduce diabetic blood glucose. This research was done by using completely randomized design (CRD) including eight treatments as follow: negative control (CMC 1%, 2 mL/200 g bw), positive control (glibenclamide 0,126 mg/200 g bw), normal control, meniran root extract in various concentration (2; 4; 6; 8; 10 mg/200 g bw). Data were elucidated until 15 day of treatment and analyzed using ANOVA followed by DMRT at 5% confidence level. The result indicated that meniran root extract giving significant effect on the reduction of blood glucose, however it does not appear to have the same result to total cholesterol content. At various concentration of meniran root extract, the total cholesterol of rat remain stable. The optimum concentration to provide hypoglicemic activity raised at 10 mg/200 b bw dose. Key words: Phyllanthus niruri L., root extract meniran, blood glucose, total cholesterol content.