PENGARUH PEMBERIAN EKSTRAK DAUN SAMBILOTO (Andrographis paniculata Ness.) TERHADAP STRUKTUR MIKROANATOMI HEPAR DAN KADAR GLUTAMAT PIRUVAT TRANSAMINASE SERUM MENCIT (Mus musculus L.) YANG TERPAPAR DIAZINON
| Main Author: | Wulandari, tri |
|---|---|
| Format: | Thesis NonPeerReviewed application/pdf |
| Terbitan: |
, 2006
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| Subjects: | |
| Online Access: |
http://eprints.uns.ac.id/4188/1/59671206200908111.pdf http://eprints.uns.ac.id/4188/ |
Daftar Isi:
- ABSTRACT Tri Wulandari. 2005. THE EFFECT OF LEAVES SAMBILOTO (Andrographis paniculata Ness.) EXTRACT ON MICROANATOMIC STRUCTURE OF LIVER AND SERUM GLUTAMATE PYRUVATE TRANSAMINASE LEVEL OF MICE (Mus musculus L.) EXPOSED TO DIAZINON. Diazinon is a pesticide which is often using by farmer to kill insect as the enemy of the plant. The over using of pesticide may result in the remaining of diazinon residue in farming product. This residue can cause the damage of body tissue, especially liver. The aim of the research were to find out the effect of leaves sambiloto (Andrographis paniculata Ness.) extract on microanatomic structure of liver and serum glutamate pyruvate transaminase (GPT) level of mice (Mus musculus L.) exposed to diazinon. The research used Complete Random Design with five treatments. The treatment of each group were using CMC 1% (placebo control), diazinon solution 40 mg/Kg BW (negative control) and the leaves sambiloto extract 12,6; 25,2 and 37,8 mg/Kg BW. Diazinon solution was given within 10 days and continued with the extract of sambiloto leaves also within 10 days. Parameter observed was the microanatomic structure of liver and serum (GPT) level. The data was analyzed of Analysis of Varians (Anova) and continued with DMRT at significance 5%. The result of the research showed that the giving of the extract of sambiloto leaves in some dose variation degree is significantly influential to repair the microanatomic stucture of liver and decrease the serum GPT level. The Extract of sambiloto leaves dose having the highest effectiveness to repair the microanatomic structure of liver and to decrease the serum GPT level was 37,8 mg/Kg BW.