CORRELATION OF URINE N-ACETYL-BETA-D-GLUCOSAMINIDASE ACTIVITY WITH URINE ALBUMIN CREATININE RATIO IN TYPE 2 DIABETES MELLITUS
| Main Authors: | Ariyanti, Melly, ., Lillah, Nasrul, Ellyza, ., Husni |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA
, 2017
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| Subjects: | |
| Online Access: |
http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/797 http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/797/554 |
Daftar Isi:
- Urine Albumin Creatinine Ratio (UACR) is method to measure microalbuminuria, it is the earliest and most commonly usedmarker of diabetic nephropathy (DN). N-acetyl-beta-d glucosaminidase (NAG) is a high molecular weight lysosomal enzyme thatcannot pass into the glomerular ultrafiltrate. Excretion of NAG is easily pertubed specially by albumin filtration. The objective ofthis study was to analyze the correlation between NAG level with UACR in type 2 Diabetes Mellitus (DM). This was an analyticalstudy with cross-sectional design in 25 type 2 diabetes mellitus outpatient in the Internal Medicine Department Dr. M. DjamilHospital Padang. The study was conducted from January-September 2016. Urine albumin was measured by the immunoturbidimetrymethod, urine creatinine was measured by Jaffe method and urine NAG was measured by enzyme-linked immune sorbent assay(ELISA) method. Data were analyzed by Spearman correlation test, significant if p<0.05. This study consisted of 68% males and 32%females. Mean of age was 56.16±7.6 years old with a range 39–67 years old. Mean of serum glucose, Urea and creatinine level, were148±49 mg/dL, 24±6.2 mg/dL and 0.9±0.3 mg/dL respectively. Normoalbuminuria was 80% and microalbuminuria 20%.Median value of UACR in type 2 DM was 6.02 (16.46) mg/g with a range of 1.53–119.41 mg/g and mean level of urine NAG was51.01±31.88 ng/mL with a range of 9.45–144.38 ng/mL. Spearman correlation test showed a strong correlation between urine NAGwith UACR in type 2 DM with r=0.614 and p<0.05. There was a strong correlation between urine NAG with UACR in type 2 DM.